Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells.
Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells.
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DOI：
10.1002/ijc.23881
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发表时间：
2009-01-01
影响因子：
6.4
通讯作者：
Levy, Ronald
中科院分区：
文献类型：
--
作者：
Ai, Weiyun Z.;Hou, Ling-Zhou;Zeiser, Robert;Czerwinski, Debra;Negrin, Robert S.;Levy, Ronald
越来越多的证据表明，表达 CD4+CD25+ FoxP3 的调节性 T 细胞 (Treg) 高度集中在肿瘤中，从而培育免疫豁免的微环境。一些研究表明，T细胞受体（TCR）刺激可以将常规T细胞转化为Treg。滤泡性淋巴瘤 B 细胞可以增强这种 Treg 转化。我们研究了 FL 肿瘤 B 细胞与正常 B 细胞相比，是否具有将效应 T 细胞转化为 Treg 细胞的独特能力。我们发现，单独的肿瘤B细胞，在没有人工TCR刺激的情况下，可以诱导常规T细胞表达FoxP3并获得调节功能。与恶性 B 细胞相反，正常 B 细胞不会诱导 Treg 转化。 Treg 转化独立于 T 细胞背景，因为从 FL 或正常外周血中分离的 T 细胞同样容易被肿瘤 B 细胞转化。我们的研究为 FL 肿瘤细胞通过诱导 Treg 促进免疫逃逸的肿瘤特异性机制提供了证据。
There has been accumulating evidence that CD4+CD25+ FoxP3 expressing regulatory T cells (Treg) are highly concentrated in tumors, thereby fostering an immune-privileged microenvironment. Some studies have shown that T cell receptor (TCR) stimulation can convert conventional T cells into Treg. Follicular lymphoma B cells can enhance this Treg conversion. We investigated whether FL tumor B cells, as opposed to normal B cells, are unique in their ability to convert effector T cells into Treg. We found that tumor B cells alone, without artificial TCR stimulation, could induce conventional T cells to express FoxP3 and to acquire regulatory function. In contrast to their malignant counterpart, normal B cells did not induce Treg conversion. Treg conversion was independent of the T cell background, since T cells isolated from FL or normal peripheral blood were equally susceptible to being converted by tumor B cells. Our study provides evidence for a tumor-specific mechanism by which FL tumor cells promote immune escape through the induction of Treg.
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影响因子：
20.3
作者：
Cerhan, James R.;Wang, Sophia;Hartge, Patricia
通讯作者：
Hartge, Patricia
影响因子：
5.4
作者：
Nakayama, T;Hieshima, K;Yoshie, O
通讯作者：
Yoshie, O
影响因子：
11.2
作者：
Sharma, S;Yang, SC;Dubinett, SM
通讯作者：
Dubinett, SM
用激动性抗GITR mAb治疗晚期肿瘤及其对肿瘤浸润Foxp3+CD25+CD4+调节T细胞的影响。
影响因子：
15.3
作者：
Ko, K;Yamazaki, S;Nakamura, K;Nishioka, T;Hirota, K;Yamaguchi, T;Shimizu, J;Nomura, T;Chiba, T;Sakaguchi, S
通讯作者：
Sakaguchi, S
DOI：
10.1073/pnas.0509484103
发表时间：
2006-04-25
影响因子：
11.1
作者：
Gavin, MA;Torgerson, TR;Rudensky, AY
通讯作者：
Rudensky, AY