Projections to layer VI of the posteromedial barrel field in the rat: a reappraisal of the role of corticothalamic pathways.
Projections to layer VI of the posteromedial barrel field in the rat: a reappraisal of the role of corticothalamic pathways.
复制标题
大鼠后内侧桶状场第六层的投影：皮质丘脑通路作用的重新评估。
作者：
Zhong;M. Deschenes
本研究涉及终止于大鼠后内侧桶状野第VI层的传入。它们的起源是由霍乱毒素的逆行运输确定的，其轴突分支是通过在含有逆行标记的神经元的区域靶向注射生物素化的葡聚糖胺来揭示的。VI层的传入来自丘脑(腹后内侧核、后内侧核和板内核)、屏状核和新皮质其他躯体运动区的颗粒下层(运动皮质、第二躯体感觉皮质和鼻周皮质)。在这些传入系统中，皮质轴突，特别是那些从运动皮质发出的轴突，在第VI层产生最丰富的投射，而丘脑和屏状传入形成稀疏的终末野。由于皮质丘脑细胞约占VI层神经元总数的50%，其73%的树突分布于局部，运动皮质颗粒下层的传入可能直接影响这些神经元的放电。这些解剖学数据表明，应该从感觉知觉是一个在运动活动指导下进行操作的主动过程的观点来研究皮质丘脑通路的作用。
The present study bears on afferents that terminate in layer VI of the posteromedial barrel field in the rat. Their origin was determined by the retrograde transport of cholera toxin, and their axonal arborizations were revealed by targeting injections of biotinylated dextran amine in regions that contained retrogradely labeled neurons. Afferents to lamina VI arise from the thalamus (the ventral posteromedial, the posterior group and the intralaminar nuclei), the claustrum and the infragranular layers of other somatomotor regions of the neocortex (the motor, second somatosensory and perirhinal cortices). Among these afferent systems, corticocortical axons, particularly those issuing from the motor cortex, give rise to the most profuse projections in layer VI, whereas thalamic and claustral afferents form sparse terminal fields. Because corticothalamic cells represent approximately 50% of the neuronal population in lamina VI and 73% of their dendritic processes are deployed locally, it seems likely that afferents arising from the infragranular layers of the motor cortex may directly influence the firing of these neurons. These anatomical data suggest that the role of corticothalamic pathways should be studied from the viewpoint that sensory perception is an active process which operates under the guidance of motor activities.
影响因子：
2.5
作者：
ARMSTRONGJAMES, M;FOX, K;DASGUPTA, A
通讯作者：
DASGUPTA, A