Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids.
Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids.
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DOI：
10.3109/10715762.2012.659248
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发表时间：
2012-04
影响因子：
3.3
通讯作者：
Cooke MS
中科院分区：
文献类型：
--
作者：
Cadet J;Loft S;Olinski R;Evans MD;Bialkowski K;Richard Wagner J;Dedon PC;Møller P;Greenberg MM;Cooke MS
一个广泛的科学界参与调查，旨在描绘的形成机制和细胞处理的氧化产生的损害核酸。也许是由于这种广泛的研究专业知识，有几个氧化碱基的命名问题，包括8-氧代-7，8-二氢鸟嘌呤（8-oxoGua），几乎每一种类型的细胞氧化应激的普遍存在的标志物。努力规范的命名和缩写的主要DNA降解产物，产生氧化途径的报告。还提供了关于主要氧化自由基、非自由基氧物种、单电子试剂和参与DNA降解途径的酶以及它们的目标和反应性的信息。还包括对DNA氧化产生的损伤的简要分类，这些损伤可能涉及单修饰、串联碱基修饰、链内和链间交联以及DNA-蛋白质交联和由脂质过氧化物分解产物产生的碱基加合物。
A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several of the oxidized bases including 8-oxo-7,8-dihydroguanine (8-oxoGua), a ubiquitous marker of almost every type of oxidative stress in cells. Efforts to standardize the nomenclature and abbreviations of the main DNA degradation products that arise from oxidative pathways are reported. Information is also provided on the main oxidative radicals, non-radical oxygen species, one-electron agents and enzymes involved in DNA degradation pathways as well in their targets and reactivity. A brief classification of oxidatively generated damage to DNA that may involve single modifications, tandem base modifications, intrastrand and interstrand cross-links together with DNA-protein cross-links and base adducts arising from the addition of lipid peroxides breakdown products is also included.
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影响因子：
3.1
作者：
Cadet, Jean;Douki, Thierry;Di Mascio, Paolo
通讯作者：
Di Mascio, Paolo
DOI：
10.1016/j.mrgentox.2011.05.010
发表时间：
2011-09-18
影响因子：
1.9
作者：
Azqueta, Amaya;Gutzkow, Kristine B.;Collins, Andrew R.
通讯作者：
Collins, Andrew R.
影响因子：
3.2
作者：
Belmadoui, Nourreddine;Boussicault, Fabien;Cadet, Jean
通讯作者：
Cadet, Jean
影响因子：
4.5
作者：
Ballmaier, D;Epe, B
通讯作者：
Epe, B
DOI：
10.1016/0165-7992(87)90101-1
发表时间：
1987-10-01
期刊：
MUTATION RESEARCH
影响因子：
--
作者：
AIDA, M;NISHIMURA, S
通讯作者：
NISHIMURA, S