The TR (i)P to Ca²⁺ signaling just got STIMy: an update on STIM1 activated TRPC channels.
The TR (i)P to Ca²⁺ signaling just got STIMy: an update on STIM1 activated TRPC channels.
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DOI：
10.2741/3958
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Singh BB
中科院分区：
文献类型：
--
作者：
Pani B;Bollimuntha S;Singh BB
钙是一种普遍存在的信号分子，从单细胞生命形式到高等真核生物的细胞代谢不可缺少。大多数真核细胞的生物学功能都是由胞浆钙的变化来调节的，这主要是通过钙库操纵的钙进入（SOCE）这一普遍现象来实现的。经典的TRP和奥赖通道已被描述为钙库操纵的钙通道（SOCC）的分子组成部分。重要的是，ER钙传感器STIM 1已被证明通过SOCC门控启动SOCE。自从STIM 1作为SOCE的关键调节因子被发现以来，已经有一系列的观察结果表明其在调节TRPC和奥赖通道功能中的强制性作用。已经做出相当大的努力来确定STIM 1如何激活SOCC的分子细节。在这种情况下，研究结果到目前为止已经大大丰富了我们的理解，SOCE的工作方式，组织STIM 1-SOCC复合物的不同细胞区域，以及STIM 1激活的SOCE的生理结果。在这篇综述中，我们讨论TRPC通道，并提供最新的功能调节STIM 1。
Calcium is a ubiquitous signaling molecule, indispensable for cellular metabolism of organisms from unicellular life forms to higher eukaryotes. The biological function of most eukaryotic cells is uniquely regulated by changes in cytosolic calcium, which is largely achieved by the universal phenomenon of store-operated calcium entry (SOCE). The canonical TRPs and Orai channels have been described as the molecular components of the store-operated calcium channels (SOCC). Importantly, the ER calcium-sensor STIM1 has been shown to initiate SOCE via gating of SOCC. Since the discovery of STIM1, as the critical regulator of SOCE, there has been a flurry of observations suggesting its obligatory role in regulating TRPC and Orai channel function. Considerable effort has been made to identify the molecular details as how STIM1 activates SOCC. In this context, findings as of yet has substantially enriched our understanding on, the modus operandi of SOCE, the distinct cellular locales that organize STIM1-SOCC complexes, and the physiological outcomes entailing STIM1-activated SOCE. In this review we discuss TRPC channels and provide an update on their functional regulation by STIM1.
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