Repellent, irritant and toxic effects of 20 plant extracts on adults of the malaria vector Anopheles gambiae mosquito.
Repellent, irritant and toxic effects of 20 plant extracts on adults of the malaria vector Anopheles gambiae mosquito.
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DOI：
10.1371/journal.pone.0082103
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Chandre F
中科院分区：
文献类型：
--
作者：
Deletre E;Martin T;Campagne P;Bourguet D;Cadin A;Menut C;Bonafos R;Chandre F
拟除虫菊酯类杀虫剂具有驱避兴奋作用，可减少人与蚊子的接触。使用杀虫剂预计会降低病原体传播的风险，特别是在浸渍在长效处理过的蚊帐上时。低剂量使用时，拟除虫菊酯类杀虫剂具有毒性作用，然而，几种蚊子对拟除虫菊酯类杀虫剂产生抗药性可能会危及这些有益作用。因此，需要找到更多的化合物，要么杀死携带疾病的蚊子，要么防止蚊子与人类接触。在实验室条件下，评估了20种植物提取物（主要是精油）对疟疾主要媒介冈比亚按蚊（Anopheles gambiae）成虫的影响（即驱避、刺激和毒性）。将它们的效果与作为阳性对照的避蚊胺和氯菊酯进行了比较。大多数植物提取物对豚鼠具有刺激、驱避和/或毒性作用。冈比亚按蚊的成年人。其中，冬菇、肉桂和寻常胸腺三种提取物的综合作用效果最好。刺激、驱避和毒性作用明显独立发生，成虫的行为反应。冈比亚受到植物提取物浓度的显著影响。因此，潜在的驱避机制可能不同于潜在的刺激性和毒性。因此，可以设想将有效的植物提取物作为拟除虫菊酯类杀虫剂的替代品用于病媒控制。
Pyrethroid insecticides induce an excito-repellent effect that reduces contact between humans and mosquitoes. Insecticide use is expected to lower the risk of pathogen transmission, particularly when impregnated on long-lasting treated bednets. When applied at low doses, pyrethroids have a toxic effect, however the development of pyrethroid resistance in several mosquito species may jeopardize these beneficial effects. The need to find additional compounds, either to kill disease-carrying mosquitoes or to prevent mosquito contact with humans, therefore arises. In laboratory conditions, the effects (i.e., repellent, irritant and toxic) of 20 plant extracts, mainly essential oils, were assessed on adults of Anopheles gambiae, a primary vector of malaria. Their effects were compared to those of DEET and permethrin, used as positive controls. Most plant extracts had irritant, repellent and/or toxic effects on An. gambiae adults. The most promising extracts, i.e. those combining the three types of effects, were from Cymbopogon winterianus, Cinnamomum zeylanicum and Thymus vulgaris. The irritant, repellent and toxic effects occurred apparently independently of each other, and the behavioural response of adult An. gambiae was significantly influenced by the concentration of the plant extracts. Mechanisms underlying repellency might, therefore, differ from those underlying irritancy and toxicity. The utility of the efficient plant extracts for vector control as an alternative to pyrethroids may thus be envisaged.
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影响因子：
5.4
作者：
Corbel V;Stankiewicz M;Pennetier C;Fournier D;Stojan J;Girard E;Dimitrov M;Molgó J;Hougard JM;Lapied B
通讯作者：
Lapied B
影响因子：
2
作者：
Amer, Abdelkrim;Mehlhorn, Heinz
通讯作者：
Mehlhorn, Heinz
影响因子：
3.3
作者：
Dabire, K. R.;Diabate, A.;Baldet, T.
通讯作者：
Baldet, T.
影响因子：
2.1
作者：
Barnard, DR
通讯作者：
Barnard, DR
DOI：
10.1007/bf01380052
发表时间：
1976-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY
影响因子：
--
作者：
DAVIS, EE;SOKOLOVE, PG
通讯作者：
SOKOLOVE, PG