MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN.
MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN.
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MiR-221 通过靶向 PTEN 促进 HER2 阳性乳腺癌的曲妥珠单抗耐药和转移
DOI：
10.5483/bmbrep.2014.47.5.165
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发表时间：
2014-05
期刊：
影响因子：
3.8
通讯作者：
Jia L
中科院分区：
文献类型：
--
作者：
Ye X;Bai W;Zhu H;Zhang X;Chen Y;Wang L;Yang A;Zhao J;Jia L
HER 2过表达乳腺癌的特征是频繁的远处转移，并且在使用单克隆抗体药物曲妥珠单抗进行短期有效治疗后通常会产生耐药性。在这里，我们发现致癌的miRNA，miR-221，抑制细胞凋亡，诱导曲妥珠单抗耐药，促进HER 2阳性乳腺癌的转移。肿瘤抑制因子PTEN被鉴定为miR-221靶标; PTEN的过表达消除了上述miR-221诱导的细胞恶性表型。这些发现表明，miR-221可能通过靶向PTEN促进HER 2阳性乳腺癌的曲妥珠单抗耐药和转移，表明其作为进展和不良预后的潜在生物标志物的作用，以及作为曲妥珠单抗联合治疗乳腺癌的新靶点。[BMB Reports 2014; 47（5）：268-273]。
HER2-overexpressing breast cancers are characterized by frequent distant metastasis and often develop resistance after short-term effective treatment with the monoclonal antibody drug, trastuzumab. Here, we found that the oncogenic miRNA, miR-221, inhibited apoptosis, induced trastuzumab resistance and promoted metastasis of HER2-positive breast cancers. The tumor suppressor PTEN was identified as a miR-221 target; overexpression of PTEN abrogated the aforementioned miR-221-induced malignant phenotypes of the cells. These findings indicate that miR-221 may promote trastuzumab resistance and metastasis of HER2-positive breast cancers by targeting PTEN, suggesting its role as a potential biomarker for progression and poor prognosis, and as a novel target for trastuzumab-combined treatment of breast cancers. [BMB Reports 2014; 47(5): 268-273].
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影响因子：
3.8
作者：
Chun-Zhi Z;Lei H;An-Ling Z;Yan-Chao F;Xiao Y;Guang-Xiu W;Zhi-Fan J;Pei-Yu P;Qing-Yu Z;Chun-Sheng K
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影响因子：
45.3
作者：
Cobleigh, MA;Vogel, CL;Slamon, DJ
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Slamon, DJ
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50.3
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影响因子：
2.5
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Eceles, SA