Molecular Subtypes and Local-Regional Control of Breast Cancer.
Molecular Subtypes and Local-Regional Control of Breast Cancer.
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DOI：
10.1016/j.soc.2017.08.005
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发表时间：
2018-01
影响因子：
1.9
通讯作者：
Jeruss JS
中科院分区：
文献类型：
--
作者：
Fragomeni SM;Sciallis A;Jeruss JS
在个性化医疗时代，乳腺癌亚型的分子分析已经取得了重大进展。主要分类方案基于基因表达谱，通常称为内在亚型，包括：管腔A型、管腔B型、HER2富集型和基底样型。研究工作集中在这些亚型的分类如何提供预后信息和影响治疗计划。癌症亚型分层已成为疾病表征的关键组成部分。虽然人们对不同分子亚型对疾病特异性生存率的影响了解很多，但最近的研究也调查了不同分子亚型对局部区域复发的作用。这是一个积极研究的领域，近年来取得了重大进展。本综述的目的是描述疾病亚型之间的结果，以帮助最佳的手术决策，以改善局部区域控制。
In the era of personalized medicine, there has been significant progress regarding the molecular analysis of breast cancer subtypes. The major classification schemes are based on gene expression profiling are often referred to as intrinsic subtypes and include:luminal A, luminal B, HER2 enriched, and basal-like. Research efforts have focused on how classification of these subtypes could provide information on prognosis and influence treatment planning. Cancer subtype stratification has become a critical component of disease characterization. While much is known about the impact of different molecular subtypes on disease-specific survival, more recent studies have also investigated the role of the different molecular subtypes on local-regional recurrence. This is an area of active study, and in recent years there has been significant progress. The goal of this review is to describe outcomes among disease subtypes to aid in optimal surgical decision-making to improve local-regional control.
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DOI：
10.1016/s1470-2045(14)70460-7
发表时间：
2014-11
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Donker M;van Tienhoven G;Straver ME;Meijnen P;van de Velde CJ;Mansel RE;Cataliotti L;Westenberg AH;Klinkenbijl JH;Orzalesi L;Bouma WH;van der Mijle HC;Nieuwenhuijzen GA;Veltkamp SC;Slaets L;Duez NJ;de Graaf PW;van Dalen T;Marinelli A;Rijna H;Snoj M;Bundred NJ;Merkus JW;Belkacemi Y;Petignat P;Schinagl DA;Coens C;Messina CG;Bogaerts J;Rutgers EJ
通讯作者：
Rutgers EJ
影响因子：
45.3
作者：
BORGER, J;KEMPERMAN, H;BARTELINK, H
通讯作者：
BARTELINK, H
影响因子：
158.5
作者：
Cardoso, F.;van't Veer, L. J.;Piccart, M.
通讯作者：
Piccart, M.
影响因子：
168.9
作者：
Davies, C.;Godwin, J.;Gray, R.;Clarke, M.;Darby, S.;McGale, P.;Wang, Y. C.;Peto, R.;Pan, H. C.;Cutter, D.;Taylor, C.;Ingle, J.
通讯作者：
Ingle, J.
影响因子：
11.5
作者：
Colleoni, M;Viale, G;Goldhirsch, A
通讯作者：
Goldhirsch, A