Persistent and widespread occurrence of bioactive quinone pigments during post-Paleozoic crinoid diversification
Persistent and widespread occurrence of bioactive quinone pigments during post-Paleozoic crinoid diversification
复制标题
后古生代海百合多样化过程中生物活性醌色素的持续和广泛存在
DOI：
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发表时间：
2015
影响因子：
11.1
通讯作者：
K. Wolkenstein
中科院分区：
文献类型：
--
作者：
K. Wolkenstein
海洋生物产生多种具有特定生物活性的天然产物，是药物发现的宝贵来源。这些次生代谢物是生产生物在进化过程中适应和自然选择的结果。然而，由于古代生物的原始次生代谢物通常不会被保存下来，因此对这些次生代谢物在较长时间内的进化持久性和分布情况知之甚少。在这里，一组生物活性醌色素的独特例子显示，从中生代早期（约240亿年前）到今天，在棘皮动物类criinoidea中几乎没有改变，分布广泛，而该类在二叠纪末大灭绝后经历了一次主要的适应性辐射和多样化。次生代谢物在生物体适应环境的过程中起着重要作用。然而，人们对古代生物的次生代谢物及其进化史知之甚少。对深海中保存异常完好的彩色海百合化石和现代海百合的化学分析表明，与金丝桃素相关的生物活性多环醌在古生代以后的海百合中是并且仍然是全球广泛存在的。在化石和现今的等红目代表植物中都发现了金丝桃素类色素，这表明自中生代以来，这些色素几乎没有改变，也表明含有金丝桃素类的古代海百合的原始颜色可能与它们的现代近亲相似。在后古生代海百合适应辐射过程中，金丝桃素类色素在不同目中持续而广泛的出现，在空间和分类上表明了这种色素的普遍功能重要性，为海百合总科的成功进化做出了贡献。
Significance Marine organisms produce a wide diversity of natural products with specific bioactivities, representing a valuable source for drug discovery. These secondary metabolites are the result of adaptation and natural selection during the evolution of the producing organisms. However, little is known about the evolutionary persistence and distribution of these secondary metabolites through deep time, because original secondary metabolites of ancient organisms usually are not preserved. Here the unique example of a group of bioactive quinone pigments is shown to have persisted almost unchanged and with a wide distribution from the Early Mesozoic (about 240 MyBP) until today within the echinoderm class Crinoidea, whereas the class underwent a major adaptive radiation and diversification after the end-Permian mass extinction. Secondary metabolites often play an important role in the adaptation of organisms to their environment. However, little is known about the secondary metabolites of ancient organisms and their evolutionary history. Chemical analysis of exceptionally well-preserved colored fossil crinoids and modern crinoids from the deep sea suggests that bioactive polycyclic quinones related to hypericin were, and still are, globally widespread in post-Paleozoic crinoids. The discovery of hypericinoid pigments both in fossil and in present-day representatives of the order Isocrinida indicates that the pigments remained almost unchanged since the Mesozoic, also suggesting that the original color of hypericinoid-containing ancient crinoids may have been analogous to that of their modern relatives. The persistent and widespread occurrence, spatially as well as taxonomically, of hypericinoid pigments in various orders during the adaptive radiation of post-Paleozoic crinoids suggests a general functional importance of the pigments, contributing to the evolutionary success of the Crinoidea.
影响因子：
5.1
作者：
Wangun, Hilaire V. Kemami;Wood, Alexander;Fiorillo, Catherine;Reed, John K.;McCarthy, Peter J.;Wrightt, Amy E.
通讯作者：
Wrightt, Amy E.