Evaluation of simultaneous 201Tl/99mTc dual-isotope cardiac SPECT imaging with model-based crosstalk compensation using canine studies.
Evaluation of simultaneous 201Tl/99mTc dual-isotope cardiac SPECT imaging with model-based crosstalk compensation using canine studies.
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DOI：
10.1007/s12350-013-9842-8
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发表时间：
2014-04
影响因子：
2.4
通讯作者：
Frey, E. C.
中科院分区：
文献类型：
--
作者：
Du, Y.;Links, J. M.;Becker, L.;DiPaula, A. F.;Frank, T.;Schuleri, K. H.;Lardo, A. C.;Frey, E. C.
同时 201Tl/99mTc-Sestamibi 双同位素心肌灌注 SPECT 成像可以减少成像时间并生成完美配准的休息/应激图像。然而，从 99mTc 到 201Tl 图像的串扰会显着降低 201Tl 图像质量。我们开发了一种基于模型的补偿（MBC）方法来补偿这种串扰。该方法之前已通过模型和模拟研究得到验证。在本研究中，我们使用犬模型评估了 MBC 方法。在 50 只体重 20-30 公斤的成年杂种犬中制造左前降支或左回旋支冠状动脉狭窄。狗在休息时注射 111 MBq (3 mCi) 的 201Tl，并进行 SPECT 研究。通过给狗注射腺苷来诱导压力，然后在压力峰值时注射 740 MBq (20 mCi) 99mTc-Sestamibi。第二项 SPECT 研究是利用 201Tl 和 99mTc 能量窗口获取的数据进行的，以提供同步双同位素投影数据。使用有序子集期望最大化 (OS-EM) 重建算法重建图像，并补偿衰减、散射和探测器响应。对于同时采集的 201Tl 数据，我们还应用 MBC 方法来补偿 99mTc 的串扰污染。如果没有补偿，99mTc 串扰会增加其余图像中估计的 201Tl 活性浓度并降低缺陷对比度。 MBC 后，201Tl 图像与注册的单同位素图像和离体计数数据非常一致。计算单同位素和双同位素研究的缺血（IS）与非缺血（NIS）区域201Tl活性浓度比。 MBC 后与离体 IS-NIS 比率的相关性为 0.815，而没有补偿的数据的相关性为 0.495。此外，IS-NIS 比率与 MBC 的回归线几乎与斜率为 0.93 的同一线平行，而没有补偿的斜率为 0.45。这些结果表明，基于模型的串扰补偿可以显着减少活体生物系统中同时采集的心肌灌注 SPECT 图像中的串扰效应。
Simultaneous 201Tl/99mTc-Sestamibi dual-isotope myocardial perfusion SPECT imaging can reduce imaging time and produce perfectly registered rest/stress images. However, crosstalk from 99mTc into 201Tl images can significantly reduce 201Tl image quality. We have developed a model-based compensation (MBC) method to compensate for this crosstalk. The method has previously been validated with phantom and simulation studies. In this study, we evaluated the MBC method using a canine model. Left anterior descending or left circumflex coronary artery stenoses were created in 50 adult mongrel dogs weighing 20–30 kg. The dogs were injected with 111 MBq (3 mCi) of 201Tl at rest, and a SPECT study acquired. Stress was induced by administering adenosine to the dog, followed by injection of 740 MBq (20 mCi) of 99mTc-Sestamibi at peak stress. A second SPECT study was performed with data acquired in both 201Tl and 99mTc energy windows to provide simultaneous dual-isotope projection data. The images were reconstructed using the ordered subsets-expectation maximization (OS-EM) reconstruction algorithm with compensation for attenuation, scatter and detector response. For simultaneously acquired 201Tl data, we also applied the MBC method to compensate for crosstalk contamination from 99mTc. Without compensation, 99mTc crosstalk increased the estimated 201Tl activity concentration in the rest images and reduced defect contrast. After MBC, the 201Tl images were in good agreement with the registered single isotope images and ex vivo count data. The ischemic (IS) to non-ischemic (NIS) region 201Tl activity concentration ratios were computed for single isotope and dual isotope studies. The correlation with ex vivo IS-NIS ratios was 0.815 after MBC, compared to the 0.495 from data without compensation. In addition, the regression line for the IS-NIS ratios with MBC was almost parallel to the line of identity with a slope of 0.93, compared to a slope of 0.45 without compensation. These results demonstrate that model-based crosstalk compensation can provide substantial reduction of crosstalk effects in simultaneously acquired myocardial perfusion SPECT images in living biological systems.
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