Interleukin-10 and tumour necrosis factor alpha promoter region polymorphisms and susceptibility to urogenital schistosomiasis in young Zimbabwean children living in Schistosoma haematobium endemic regions.
Interleukin-10 and tumour necrosis factor alpha promoter region polymorphisms and susceptibility to urogenital schistosomiasis in young Zimbabwean children living in Schistosoma haematobium endemic regions.
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DOI：
10.4102/sajid.v35i1.11
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发表时间：
2020
影响因子：
0.9
通讯作者：
Mduluza T
中科院分区：
文献类型：
--
作者：
Marume A;Vengesai A;Mann J;Mduluza T
Host genetic factors can influence susceptibility, morbidity and mortality from schistosomiasis. The study explored the association between single nucleotide polymorphisms (SNPs) in interleukin-10 (IL-10) and tumour necrosis factor alpha (TNF-α) promoter regions and susceptibility to Schistosoma haematobium infection. Urine specimens were collected from 361 primary school children aged 5–15 years from schistosomiasis endemic areas of Manicaland and Mashonaland central provinces. Schistosoma haematobium was diagnosed using the urine filtration method. Only 272 participants provided adequate blood for genotyping. Genotyping was performed using the amplification refractory mutation system-polymerase chain reaction. The association between IL-10 and TNF-α SNPs and S. haematobium infection was analysed using the chi-square test. Schistosoma haematobium infection was confirmed in 26.8% of the participants. No significant difference in S. haematobium prevalence between men (51.6% of those infected) and women (48.4%) (χ2 = 0.008, df = 1, p = 0.928) was observed. The total IL-10 -1082 G, IL-10 -819 C and TNF-α -308G allele distribution between S. haematobium infected and uninfected participants was 50.7% and 51.5% (χ2 = 0.025, df = 1, p = 0.87), 54.3% and 60.6% (χ2 = 1.187, df = 1, p = 0.187) and 82.1% and 80.9% (χ2 = 0.099, df = 1, p = 0.753), respectively, and the differences were not significant. Interleukin-10 -1082 G/A, IL-10 -819 C/T and TNF-α -308 G/A SNPs were not significantly associated with susceptibility to S. haematobium infection. The prevalence of schistosomiasis is still in the moderate range and is similar in boys and girls.
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影响因子：
10.7
作者：
Khaled H
通讯作者：
Khaled H
影响因子：
2.7
作者：
Nyati-Jokomo, Zibusiso;Chimbari, Moses J.
通讯作者：
Chimbari, Moses J.
影响因子：
9.8
作者：
Dessein, AJ;Hillaire, D;Abel, L
通讯作者：
Abel, L
影响因子：
7.3
作者：
Alexander J;Brombacher F
通讯作者：
Brombacher F
影响因子：
6.4
作者：
Koukounari, Artemis;Gabrielli, Albis F.;Webster, Joanne P.
通讯作者：
Webster, Joanne P.