Trends in the incidence, demographics, and outcomes of end-stage renal disease due to lupus nephritis in the US from 1995 to 2006.
Trends in the incidence, demographics, and outcomes of end-stage renal disease due to lupus nephritis in the US from 1995 to 2006.
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DOI：
10.1002/art.30293
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发表时间：
2011-06
影响因子：
--
通讯作者：
Winkelmayer, Wolfgang C.
中科院分区：
文献类型：
--
作者：
Costenbader, Karen H.;Desai, Amrita;Alarcon, Graciela S.;Hiraki, Linda T.;Shaykevich, Tamara;Brookhart, M. Alan;Massarotti, Elena;Lu, Bing;Solomon, Daniel H.;Winkelmayer, Wolfgang C.
目前尚不清楚狼疮性肾炎 (LN) 治疗的最新进展是否导致继发于 LN 的终末期肾病 (ESRD) 发生率发生变化，或者导致 LN ESRD 患者的特征、治疗和结果发生变化。在美国肾脏数据系统中确定了发生 LN ESRD 的患者（1995-2006 年）。评估了社会人口统计学和临床特征的趋势。我们使用泊松回归测试了社会人口群体标准化发病率 (SIR) 的时间变化。使用粗略和调整后的事件发生时间分析来检查肾移植等候名单、肾移植和全因死亡率的变化。已确定 12,344 例 LN ESRD 病例。 ESRD 发病的平均年龄为 41 岁； 81.6% 为女性，49.5% 为非裔美国人。 1995 年至 2006 年间，5-39 岁人群、非裔美国人以及美国东南部地区的 LN ESRD 的 SIR 显着增加。检测到体重指数增加以及糖尿病和高血压的患病率增加。 ESRD 发病时的平均血清血红蛋白增加，而血清肌酐随着时间的推移而下降。使用血液透析的患者较多，腹膜透析的患者较少。 ESRD 发病时先发制人的肾移植率略有增加，但 ESRD 前三年内的肾移植率有所下降。经过 12 年的研究，死亡率没有变化。 LN ESRD 患者的特征及其初始治疗近年来发生了变化。尽管年轻患者、非裔美国人和南方患者的 SIR 有所上升，但在十多年的评估中，结果并没有改善。
It is unknown whether recent advances lupus nephritis (LN) treatment have led to changes in the incidence of end-stage renal disease (ESRD) secondary to LN, or in the characteristics, therapies, and outcomes of patients with LN ESRD. Patients with incident LN ESRD (1995–2006) were identified in the US Renal Datasystem. Trends in sociodemographic and clinical characteristics were assessed. We tested for temporal changes in standardized incidence rates (SIRs) for sociodemographic groups using Poisson regression. Changes in rates of waitlisting for kidney transplant, kidney transplantation, and all-cause mortality were examined using crude and adjusted time-to-event analyses. 12,344 incident cases of LN ESRD were identified. Mean age at ESRD onset was 41 years; 81.6% were female and 49.5% African American. SIRs for LN ESRD among those ages 5–39, African Americans, and in the US Southeast increased significantly from 1995–2006. Increases in body mass index and the prevalence of both diabetes and hypertension were detected. Mean serum hemoglobin at ESRD onset increased, while that of serum creatinine decreased over time. More patients used hemodialysis and fewer peritoneal dialysis. There was a slight increase in pre-emptive kidney transplantation at ESRD onset, but kidney transplantation rates within the first three years of ESRD declined. Mortality did not change over 12 years of study. The characteristics of LN ESRD patients and their initial therapies have changed in recent years. While SIRs rose in younger patients, among African Americans and in the South, outcomes did not improve in over a decade of evaluation.
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影响因子：
2.1
作者：
Tang, Hongying;Chelamcharla, Madhukar;Goldfarb-Rumyantzev, Alexander S.
通讯作者：
Goldfarb-Rumyantzev, Alexander S.
影响因子：
5.9
作者：
APPEL, GB;COHEN, DJ;ESTES, D
通讯作者：
ESTES, D
影响因子：
2.6
作者：
Ponticelli, C;Moroni, G
通讯作者：
Moroni, G
影响因子：
1.5
作者：
Danieli, MG;Palmieri, C;Danieli, G
通讯作者：
Danieli, G
影响因子：
2.6
作者：
Carreño, L;López-Longo, FJ;Lapointe, N
通讯作者：
Lapointe, N