Etiology of Kidney Diseases With Proteinuria in the Gambia/West Africa.
Etiology of Kidney Diseases With Proteinuria in the Gambia/West Africa.
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DOI：
10.3389/fped.2022.854719
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发表时间：
2022
影响因子：
2.6
通讯作者：
Corrah T
中科院分区：
文献类型：
--
作者：
Vester U;Fombah A;Hölscher M;Garba D;Tapgun M;N'Jai PC;Mendy P;Bass G;Muhammad AK;Anderson ST;Sanneh A;Onyeama C;Helmchen U;Bojang K;Hoyer PF;Corrah T
In West Africa, kidney diseases are frequently seen, but diagnostic and therapeutic options are poor due to limited access to specialized facilities. To unravel the etiology and develop clinical guidelines, we collected clinical data and results of kidney biopsies in 121 pediatric and mostly young adult patients with edema and proteinuria in The Gambia. Workup included clinical examination, urine and serum analysis, and kidney biopsy findings. Selected cases were treated with steroids. The median age was 14.9 years (range 1.8–52.0) at presentation. The most frequent underlying histologies were post-infectious glomerulonephritis (PIGN) in 38%, focal-segmental glomerulosclerosis (FSGS) in 30%, minimal change nephrotic syndrome (MCNS) in 15%, and membranous glomerulonephritis (MGN) in 10% of cases. Patients with PIGN were significantly younger and had less proteinuria and higher serum albumin levels than the other three. Infected scabies was seen more often in cases with PIGN. Clinical parameters could not distinguish patients with FSGS, MCNS, and MGN. Steroid response was prompt in patients with MCNS (remission in 10/10 cases) compared to FSGS (4/19) and MGN (0/4). In summary, the clinical histopathological correlation allows a better approach to therapy and can be the basis for urgently needed interventional studies in steroid-resistant cases.
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DOI：
10.1126/science.1193032
发表时间：
2010-08-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Pollak MR
影响因子：
3
作者：
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通讯作者：
Naicker, Thajasvarie
DOI：
10.1016/0035-9203(73)90112-0
发表时间：
1973-01-01
影响因子：
2.2
作者：
WHITTLE, HC;ABDULLAHI, MT;RAJKOVIC, AD
通讯作者：
RAJKOVIC, AD
影响因子：
82.9
作者：
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DOI：
10.2215/cjn.01190210
发表时间：
2010-11-01
影响因子：
9.8
作者：
Buescher, Anja K.;Kranz, Birgitta;Konrad, Martin
通讯作者：
Konrad, Martin