Procession to pediatric bacteremia and sepsis: covert operations and failures in diplomacy.
Procession to pediatric bacteremia and sepsis: covert operations and failures in diplomacy.
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DOI：
10.1542/peds.2009-3169
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发表时间：
2010-07
期刊：
影响因子：
8
通讯作者：
Seed PC
中科院分区：
文献类型：
--
作者：
Bateman SL;Seed PC
尽管在诊断和治疗方面取得了进展，但细菌性脓毒症仍然是儿科发病率和死亡率的主要原因，特别是在新生儿、危重病患者和不断增长的免疫功能低下患者群体中。脓毒症是一系列复杂和动态事件的终点，其中宿主和微生物因素驱动高发病率和潜在致命的生理变化。本文简要概述了导致儿科血流感染（BSI）和败血症的事件，重点是细菌破坏宿主屏障和局部免疫以进入并持续存在于体循环中的分子机制。在BSI和脓毒症之前和期间的事件中，革兰氏阳性和革兰氏阴性病原体采用一系列因素进行易位、免疫抑制、分子模拟、细胞内存活和营养清除。在理解细菌BSI和脓毒症的分子发病机制方面的差距被强调为识别和开发新疗法的机会。
Despite advances in diagnosis and treatment, bacterial sepsis remains a major cause of pediatric morbidity and mortality, particularly among neonates, the critically ill, and the growing immunocompromised patient population. Sepsis is the endpoint of a complex and dynamic series of events in which both host and microbial factors drive the high morbidity and potentially lethal physiological alterations. This article provides a succinct overview of the events that lead to pediatric bloodstream infections (BSI) and sepsis, with a focus on the molecular mechanisms employed by bacteria to subvert host barriers and local immunity to gain access to and persist within the systemic circulation. In the events preceding and during BSI and sepsis, gram-positive and gram-negative pathogens employ a battery of factors for translocation, inhibition of immunity, molecular mimicry, intracellular survival, and nutrient scavenging. Gaps in understanding the molecular pathogenesis of bacterial BSI and sepsis are highlighted as opportunities to identify and develop new therapeutics.
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影响因子：
4.2
作者：
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通讯作者：
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DOI：
10.1073/pnas.0511017103
发表时间：
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