Clinical verification of body mass index and tumor immune response in patients with breast cancer receiving preoperative chemotherapy.
Clinical verification of body mass index and tumor immune response in patients with breast cancer receiving preoperative chemotherapy.
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DOI：
10.1186/s12885-021-08857-7
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发表时间：
2021-10-20
期刊：
影响因子：
3.8
通讯作者：
Ohira M
中科院分区：
文献类型：
--
作者：
Takada K;Kashiwagi S;Asano Y;Goto W;Ishihara S;Morisaki T;Shibutani M;Tanaka H;Hirakawa K;Ohira M
体重指数（BMI）通常用作肥胖的简单指标;根据BMI测量结果肥胖（OB）的早期乳腺癌患者已被证明具有高术后复发率和低生存率。另一方面，已经表明，参与肿瘤免疫应答的恶性肿瘤附近存在的淋巴细胞影响化疗的功效。因此，我们假设OB乳腺癌患者的肿瘤浸润淋巴细胞（TIL）密度较低，这可能会影响术前化疗（POC）的治疗效果。在本研究中，我们测量了接受POC的乳腺癌患者的治疗前BMI和TILs，检查了这两个因素之间的相关性，并回顾性分析了其治疗结果和并发症。这项研究的参与者是421名乳腺癌患者，他们在2007年2月至2019年1月期间接受了POC后的手术治疗。在POC前测量患者的身高和体重，以计算BMI（体重[kg]除以身高[m2]的平方）。根据世界卫生组织的分类，体重低于18.5 kg/m2的患者被归类为体重不足（UW），≥18.5 kg/m2且> 25 kg/m2的患者被视为正常体重（NW），≥25 kg/m2且< 30 kg/m2的患者被归类为超重（OW），≥30 kg/m2的患者被归类为肥胖。根据国际TIL工作组2014的定义，TIL是浸润肿瘤基质的那些淋巴细胞。中位BMI为21.9 kg/m2（范围：14.3-38.5 kg/m2）;大多数患者（244例; 64.5%）为NW。在所有378例乳腺癌患者中，OB患者的TIL密度显著低于NW和OW患者（vs. NW：p = 0.001; vs. OW：p = 0.003）。此外，当单独检查每种乳腺癌类型的患者时，具有低BMI的TNBC患者的OS显著差于其高BMI对应者（对数秩p = 0.031）。我们的数据并不支持肥胖影响肿瘤免疫微环境的假设;然而，我们发现UW确实影响肿瘤免疫微环境。在线版本包含补充材料，可通过10.1186/s12885-021-08857-7获得。
The body mass index (BMI) is commonly used as a simple indicator of obesity; patients with early-stage breast cancer who are obese (OB) per BMI measurements have been shown to have high postoperative recurrence and low survival rates. On the other hand, it has been shown that lymphocytes present in the vicinity of malignant growths that are involved in the tumors’ immune responses influence the efficacy chemotherapy. Therefore, we hypothesized that OB patients with breast cancer have a lower density of tumor-infiltrating lymphocytes (TILs), which may influence the therapeutic effect of preoperative chemotherapy (POC). In this study, we measured pretreatment BMI and TILs in patients with breast cancer who underwent POC, examined the correlations between these two factors, and retrospectively analyzed their therapeutic outcomes and prognoses. The participants in this study were 421 patients with breast cancer who underwent surgical treatment after POC between February 2007 and January 2019. The patient’s height and weight were measured before POC to calculate the BMI (weight [kg] divided by the square of the height [m2]). According to the World Health Organization categorization, patients who weighed under 18.5 kg/m2 were classified as underweight (UW), those ≥18.5 kg/m2 and > 25 kg/m2 were considered normal weight (NW), those ≥25 kg/m2 and < 30 kg/m2 were overweight (OW), and those ≥30 kg/m2 were OB. The TILs were those lymphocytes that infiltrated the tumor stroma according to the definition of the International TILs Working Group 2014. The median BMI was 21.9 kg/m2 (range, 14.3–38.5 kg/m2); most patients (244; 64.5%) were NW. Among all 378 patients with breast cancer, the TIL density was significantly lower in OB than in NW and OW patients (vs. NW: p = 0.001; vs. OW: p = 0.003). Furthermore, when examining patients with each breast cancer type individually, the OS of those with TNBC who had low BMIs was significantly poorer than that of their high-BMI counterparts (log rank p = 0.031). Our data did not support the hypothesis that obesity affects the tumor immune microenvironment; however, we showed that being UW does affect the tumor immune microenvironment. The online version contains supplementary material available at 10.1186/s12885-021-08857-7.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
影响因子：
6.2
作者：
Gennari, R;Curigliano, G;Goldhirsch, A
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影响因子：
45.3
作者：
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影响因子：
3.8
作者：
Jeon, Ye Won;Kang, Su Hwan;Suh, Young Jin
通讯作者：
Suh, Young Jin
影响因子：
45.3
作者：
Goodwin, PJ;Ennis, M;Hood, N
通讯作者：
Hood, N