Bariatric Surgery Ameliorates Diabetic Cardiac Dysfunction by Inhibiting ER Stress in a Diabetic Rat Model
Bariatric Surgery Ameliorates Diabetic Cardiac Dysfunction by Inhibiting ER Stress in a Diabetic Rat Model
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减肥手术通过抑制糖尿病大鼠模型中的内质网应激来改善糖尿病性心脏功能障碍
DOI：
10.1007/s11695-016-2492-6
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发表时间：
2017-05
期刊：
影响因子：
2.9
通讯作者：
Hu Sanyuan
中科院分区：
文献类型：
--
作者：
Zhang Xiaoqian;Liu Shaozhuang;Zhang Guangyong;Zhong Mingwei;Liu Teng;Wei Meng;Wu Dong;Huang Xin;Cheng Yugang;Wu Qunzheng;Hu Sanyuan
BackgroundCardiac dysfunction is a severe complication of diabetes, with no effective treatment. Currently, bariatric surgery is more and more widely used to attenuate diabetes-associated diseases. The mechanism is not clear. Endoplasmic reticulum (ER) stress-dependent apoptosis has been observed in the progression of diabetic myocardium damage. Therefore, this research was designed to investigate the effects of different bariatric procedures on cardiac dysfunction via ER stress-induced cardiomyocyte apoptosis pathway in a diabetic rat model.MethodsDuodenal-jejunal bypass (DJB), sleeve gastrectomy (SG), and sham surgery were performed in diabetic rats. Echocardiographic examination, H&E staining, Masson staining, and TUNEL staining were performed to measure the diabetes-caused heart damages. ER stress-associated signaling molecules like glucose-regulated protein 78 (GRP78), protein kinase RNA (PKR)-like ER protein kinase (PERK), p-PERK, inositol-requiring enzyme 1ɑ (IRE1ɑ), p-IRE1ɑ, activating transcription factor 6 (ATF6), C/EBP homologous protein (CHOP), and caspase 12 were measured and compared among DJB group, SG group, and sham group.ResultsCompared with sham group, DJB and SG groups both had significantly lower GRP78, PERK, p-PERK, CHOP, and caspase 12, though there was no statistical change on IRE1ɑ, p-IRE1ɑ, and ATF6. DJB and SG groups also showed improved heart function and lower cardiomyocyte apoptosis in diabetic rats.ConclusionDJB and SG ameliorated cardiac dysfunction by inhibiting PERK-mediated pathway. And no difference was observed on the effects of DJB and SG on ER stress-dependent myocardium damage in diabetic rats.
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影响因子：
2.9
作者：
T. Masuda;M. Ohta;T. Hirashita;Yuichiro Kawano;H. Eguchi;K. Yada;Y. Iwashita;S. Kitano
通讯作者：
T. Masuda;M. Ohta;T. Hirashita;Yuichiro Kawano;H. Eguchi;K. Yada;Y. Iwashita;S. Kitano
糖尿病心肌病的内质网应激和蛋白质质量控制。
DOI：
10.1016/j.bbadis.2014.05.006
发表时间：
2015-02
期刊：
BBA - Molecular Basis of Disease
影响因子：
--
作者：
Yang L;Zhao D, Ren J;Yang J
通讯作者：
Yang J
影响因子：
9
作者：
Liu Z;Lv Y;Zhao N;Guan G;Wang J
通讯作者：
Wang J
影响因子：
4.4
作者：
Ashrafian, Hutan;Li, Jia V.;Athanasiou, Thanos
通讯作者：
Athanasiou, Thanos
影响因子：
3.5
作者：
Guo, Rong;Liu, Weijing;Xu, Yawei
通讯作者：
Xu, Yawei