Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy.
Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy.
复制标题
糖尿病心肌病的内质网应激和蛋白质质量控制。
DOI：
10.1016/j.bbadis.2014.05.006
复制
发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Yang L;Zhao D, Ren J;Yang J
Endoplasmic reticulum (ER) stress, together with the unfolded protein response (UPR), is initially considered an adaptive response aiming at maintenance of ER homeostasis. Nonetheless, ER stress, when in excess, can eventually trigger cell apoptosis and loss of function. UPR is mediated by three major transmembrane proteins, including inositol-requiring enzyme 1 (IRE1), protein kinase RNA-like ER kinase (PERK), and activating transcription factor (ATF) 6. A unique role has been speculated for ER stress in the pathogenesis of diabetes mellitus (DM) and its complications. Recent studies have shown that ER stress is an early event associated with diabetic cardiomyopathy, and may be triggered by hyperglycemia, free fatty acids (FFAs) and inflammation. In this mini-review, we attempted to discuss the activation machinery for ER stress in response to these triggers en route to disrupted ER function and cellular autophagy or apoptosis, ultimately insulin resistance and development of diabetic cardiomyopathy. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases.
登录
查看更多内容
DOI：
10.1073/pnas.252341799
发表时间：
2002-12-10
影响因子：
11.1
作者：
Yan, W;Frank, CL;Katze, MG
通讯作者：
Katze, MG
影响因子：
2
作者：
Gotoh T;Endo M;Oike Y
通讯作者：
Oike Y
影响因子：
8
作者：
Rzymski, T.;Milani, M.;Harris, A. L.
通讯作者：
Harris, A. L.
人类胰岛素基因的七种突变与永久性新生儿/婴幼儿糖尿病有关
影响因子：
15.9
作者：
Colombo, Carlo;Porzio, Ottavia;Barbetti, Fabrizio
通讯作者：
Barbetti, Fabrizio
DOI：
10.1152/ajpendo.00038.2010
发表时间：
2010-11-01
影响因子：
5.1
作者：
Deldicque, Louise;Cani, Patrice D.;Baar, Keith
通讯作者：
Baar, Keith