Guava Leaf Extract Diminishes Hyperglycemia and Oxidative Stress, Prevents β-Cell Death, Inhibits Inflammation, and Regulates NF-kB Signaling Pathway in STZ Induced Diabetic Rats.
Guava Leaf Extract Diminishes Hyperglycemia and Oxidative Stress, Prevents β-Cell Death, Inhibits Inflammation, and Regulates NF-kB Signaling Pathway in STZ Induced Diabetic Rats.
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DOI：
10.1155/2018/4601649
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发表时间：
2018
影响因子：
--
通讯作者：
Chung SSM
中科院分区：
文献类型：
--
作者：
Jayachandran M;Vinayagam R;Ambati RR;Xu B;Chung SSM
传统中医药已被中国医生用于治疗糖尿病（DM）的各种症状。值得注意的是，番石榴叶在亚洲被用于治疗糖尿病。本研究旨在从分子水平分析番石榴叶提取物（GLE）治疗糖尿病的作用。采用小剂量链脲佐菌素（STZ）诱发动物实验性糖尿病。大鼠接受不同浓度（100、200和400 mg/kg b.w.）的GLE给药。标准药物格列本脲（GB）（600 μg/kg b.w.）用于比较。与对照组相比，糖尿病大鼠胰岛素水平降低，血糖升高，脂质过氧化产物增多，炎症细胞因子表达增加，抗氧化剂水平降低。补充GLE抵消了STZ的后果。其抑制氧化应激并抑制炎症状态，结果与标准药物组（GB组5）几乎相似。因此，我们目前的研究通过对糖尿病管理的全面评估，提供了有关番石榴叶提取物的有用数据。作为一种天然产物，对GLE的进一步分析可以揭示在糖尿病领域中寻找有效的植物化学物质。
Traditional Chinese medication has been utilized by Chinese medical practitioners to treat the varied symptoms of diabetes mellitus (DM). Notably, guava leaf has been used to treat diabetes in Asia. Our present study has been designed to analyze the action of guava leaf extract (GLE) at the molecular level in treating DM. A low dose of streptozotocin (STZ) was used to induce experimental diabetes in animals. Rats were treated with GLE at different concentrations (100, 200, and 400 mg/kg b.w.). The standard drug glibenclamide (GB) (600 μg/kg b.w.) was used for comparison. The diabetic rats showed a reduced level of insulin, accompanied by exaggerated levels of blood glucose, lipid peroxidation product, and augmented expressions of inflammatory cytokines, and showed reduced levels of antioxidants compared to the control rats. Supplementation with GLE counteracted the consequences of STZ. It suppresses the oxidative stress and inhibits the state of inflammation and the results are almost similar to that of standard drug group (GB group 5). Our present research, therefore, provides useful data concerning guava leaf extract by a thorough assessment in diabetes management. Being a natural product, additional analysis on GLE can shed light on finding effective phytochemicals within the field of diabetes mellitus.
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影响因子：
6.1
作者：
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通讯作者：
Kilinc, I
影响因子：
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0.5
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2.9
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影响因子：
7.4
作者：
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通讯作者：
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