BMI at Age 8 Years Is Influenced by the Type 2 Diabetes Susceptibility Genes HHEX-IDE and CDKAL1
BMI at Age 8 Years Is Influenced by the Type 2 Diabetes Susceptibility Genes HHEX-IDE and CDKAL1
复制标题
8 岁时的 BMI 受到 2 型糖尿病易感基因 HHEX-IDE 和 CDKAL1 的影响
作者：
C. Winkler;E. Bonifacio;H. Grallert;L. Henneberger;T. Illig;A. Ziegler
目的探讨与出生体重和2型糖尿病易感性相关的HHEX-IDE和CDKAL1基因是否继续影响儿童时期的生长发育。研究设计与方法对德国BABYDIAB队列中646名前瞻性跟踪的儿童进行HHEX-IDE和CDKAL1基因座的单核苷酸多态基因分型。所有的孩子都是独生子女，其中386人的母亲患有1型糖尿病，260人的父亲患有1型糖尿病，母亲没有糖尿病。结果在8岁时，HHEX-IDE基因座上的2型糖尿病风险等位基因与体重指数抑郁降低相关(每个等位基因0.17SDS；P=0.004)。出生体重分层后，在出生时大于胎龄儿(第90百分位数)中，HHEX-IDE和CDKAL1风险等位基因均与体重-抑郁降低(0.45SDS，P=0.0002；0.52SDS，P=0.0001)和体重-抑郁(0.22SDS，P=0.04；0.56SDS，P=0.0002)相关，但与小于或适合胎龄的儿童无关。在出生时胎龄较大的儿童中，体重指数和体重随着2型糖尿病风险等位基因的增加而下降(每个等位基因∼−为2公斤；总共为8公斤)。1型糖尿病母亲的孩子(P<；0.0001)和非糖尿病母亲的孩子(P=0.008)的研究结果是一致的。结论HHEX-IDE和CDKAL1基因座的2型糖尿病易感基因与8岁出生时体重指数偏低有关。
OBJECTIVE To determine whether HHEX-IDE and CDKAL1 genes, which are associated with birth weight and susceptibility to type 2 diabetes, continue to influence growth during childhood. RESEARCH DESIGN AND METHODS BMI, weight, and height at age 8 years expressed as age- and sex-corrected standard deviation scores (SDS) against national reference data and single-nucleotide polymorphism genotyping of HHEX-IDE and CDKAL1 loci were analyzed in 646 prospectively followed children in the German BABYDIAB cohort. All children were singleton full-term births; 386 had mothers with type 1 diabetes, and 260 had fathers with type 1 diabetes and a nondiabetic mother. RESULTS Type 2 diabetes risk alleles at the HHEX-IDE locus were associated with reduced BMI-SDS at age 8 years (0.17 SDS per allele; P = 0.004). After stratification for birth weight, both HHEX-IDE and CDKAL1 risk alleles were associated with reduced BMI-SDS (0.45 SDS, P = 0.0002; 0.52 SDS, P = 0.0001) and weight-SDS (0.22 SDS, P = 0.04; 0.56 SDS, P = 0.0002) in children born large for gestational age (>90th percentile) but not children born small or appropriate for gestational age. Within children born large for gestational age, BMI and weight decreased with each additional type 2 diabetes risk allele (∼ −2 kg per allele; >8 kg overall). Findings were consistent in children of mothers with type 1 diabetes (P < 0.0001) and children of nondiabetic mothers (P = 0.008). CONCLUSIONS The type 2 diabetes susceptibility alleles at HHEX-IDE and CDKAL1 loci are associated with low BMI at age 8 years in children who were born large for gestational age.
影响因子：
37.8
作者：
Curhan, GC;Willett, WC;Stampfer, MJ
通讯作者：
Stampfer, MJ