Potential Neuroprotective Mechanisms of Methamphetamine Treatment in Traumatic Brain Injury Defined by Large-Scale IonStar-Based Quantitative Proteomics.
Potential Neuroprotective Mechanisms of Methamphetamine Treatment in Traumatic Brain Injury Defined by Large-Scale IonStar-Based Quantitative Proteomics.
复制标题
DOI：
10.3390/ijms22052246
复制
发表时间：
2021-02-24
影响因子：
5.6
通讯作者：
Qu J
中科院分区：
文献类型：
--
作者：
Shen S;Zhang M;Ma M;Rasam S;Poulsen D;Qu J
Although traumatic brain injury (TBI) causes hospitalizations and mortality worldwide, there are no approved neuroprotective treatments, partly due to a poor understanding of the molecular mechanisms underlying TBI neuropathology and neuroprotection. We previously reported that the administration of low-dose methamphetamine (MA) induced significant functional/cognitive improvements following severe TBI in rats. We further demonstrated that MA mediates neuroprotection in part, via dopamine-dependent activation of the PI3K-AKT pathway. Here, we further investigated the proteomic changes within the rat cortex and hippocampus following mild TBI (TM), severe TBI (TS), or severe TBI plus MA treatment (TSm) compared to sham operated controls. We identified 402 and 801 altered proteins (APs) with high confidence in cortical and hippocampal tissues, respectively. The overall profile of APs observed in TSm rats more closely resembled those seen in TM rather than TS rats. Pathway analysis suggested beneficial roles for acute signaling through IL-6, TGFβ, and IL-1β. Moreover, changes in fibrinogen levels observed in TSm rats suggested a potential role for these proteins in reducing/preventing TBI-induced coagulopathies. These data facilitate further investigations to identify specific pathways and proteins that may serve as key targets for the development of neuroprotective therapies.
登录
查看更多内容
影响因子：
3.4
作者：
Kobeissy FH;Guingab-Cagmat JD;Zhang Z;Moghieb A;Glushakova OY;Mondello S;Boutté AM;Anagli J;Rubenstein R;Bahmad H;Wagner AK;Hayes RL;Wang KK
通讯作者：
Wang KK
影响因子：
4.3
作者：
Prins M;Greco T;Alexander D;Giza CC
通讯作者：
Giza CC
脑外伤后激活转化生长因子-β 和骨形态发生蛋白信号通路可抑制促炎症反应，并促进反应性星形胶质细胞和小胶质细胞的组织修复反应
影响因子：
4.8
作者：
Divolis, Georgios;Stavropoulos, Athanasios;Sideras, Paschalis
通讯作者：
Sideras, Paschalis
影响因子：
5.3
作者：
Rau, Thomas F.;Kothiwal, Aakriti S.;Poulsen, David J.
通讯作者：
Poulsen, David J.
影响因子：
4.4
作者：
Shen X;Shen S;Li J;Hu Q;Nie L;Tu C;Wang X;Orsburn B;Wang J;Qu J
通讯作者：
Qu J