The pathophysiology of traumatic brain injury at a glance.
The pathophysiology of traumatic brain injury at a glance.
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DOI：
10.1242/dmm.011585
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发表时间：
2013-11
影响因子：
4.3
通讯作者：
Giza CC
中科院分区：
文献类型：
--
作者：
Prins M;Greco T;Alexander D;Giza CC
创伤性脑损伤（TBI）被定义为大脑在颅骨内的撞击、穿透或快速移动，导致精神状态改变。创伤性脑损伤的发生率高于任何其他疾病，包括乳腺癌、艾滋病、帕金森病和多发性硬化症，并影响所有年龄组和男女。在美国和欧洲，由于受伤的运动员和军人受到宣传，这种流行病的严重程度引起了全国的关注。公众意识的提高揭示了一些关于TBI的未回答的问题，我们越来越意识到，对于影响数百万人的危机，缺乏治疗方案。虽然每例TBI都是独特的，受影响的个体表现出不同程度的损伤，不同的损伤区域模式和不同的恢复概况，但本文和随附的海报旨在说明TBI的一些常见的潜在神经化学和代谢反应。识别这些复发特征可以阐明早期干预的潜在治疗靶点。
Traumatic brain injury (TBI) is defined as an impact, penetration or rapid movement of the brain within the skull that results in altered mental state. TBI occurs more than any other disease, including breast cancer, AIDS, Parkinson’s disease and multiple sclerosis, and affects all age groups and both genders. In the US and Europe, the magnitude of this epidemic has drawn national attention owing to the publicity received by injured athletes and military personnel. This increased public awareness has uncovered a number of unanswered questions concerning TBI, and we are increasingly aware of the lack of treatment options for a crisis that affects millions. Although each case of TBI is unique and affected individuals display different degrees of injury, different regional patterns of injury and different recovery profiles, this review and accompanying poster aim to illustrate some of the common underlying neurochemical and metabolic responses to TBI. Recognition of these recurrent features could allow elucidation of potential therapeutic targets for early intervention.
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