A Skeletal Muscle-Centric View on Time-Restricted Feeding and Obesity under Various Metabolic Challenges in Humans and Animals.

Nearly 50% of adults will suffer from obesity in the U.S. by 2030. High obesity rates can lead to high economic and healthcare burdens in addition to elevated mortality rates and reduced health span in patients. Emerging data demonstrate that obesity is a multifactorial complex disease with various etiologies including aging, a lifestyle of chronic high-fat diets (HFD), genetic predispositions, and circadian disruption. Time-restricted feeding/eating (TRF; TRE in humans) is an intervention demonstrated by studies to show promise as an effective alternative therapy for ameliorating the effects of obesity and metabolic disease. New studies have recently suggested that TRF/TRE modulates the skeletal muscle which plays a crucial role in metabolism historically observed to be impaired under obesity. Here we discuss recent findings regarding potential mechanisms underlying TRF’s modulation of skeletal muscle function, metabolism, and structure which may shed light on future research related to TRF as a solution to obesity.

到2030年，美国近50%的成年人将患有肥胖症。高肥胖率除了会导致患者死亡率上升和健康寿命缩短外，还会带来高昂的经济和医疗负担。新出现的数据表明，肥胖是一种多因素复杂疾病，其病因多样，包括衰老、长期高脂肪饮食的生活方式、遗传倾向以及昼夜节律紊乱。限时进食（在人类中为限时饮食）是一种经研究证明有希望作为缓解肥胖和代谢疾病影响的有效替代疗法的干预措施。最近的新研究表明，限时进食/限时饮食可调节骨骼肌，骨骼肌在新陈代谢中起着至关重要的作用，而在肥胖情况下，其新陈代谢历来被观察到会受损。在这里，我们讨论关于限时进食对骨骼肌功能、代谢和结构调节的潜在机制的最新发现，这些发现可能会为限时进食作为肥胖解决方案的相关未来研究提供启示。