Enzyme-triggered nanomedicine: drug release strategies in cancer therapy.
Enzyme-triggered nanomedicine: drug release strategies in cancer therapy.
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DOI：
10.3109/09687688.2010.515950
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发表时间：
2010-10
影响因子：
--
通讯作者：
Kaasgaard T
中科院分区：
文献类型：
--
作者：
Andresen TL;Thompson DH;Kaasgaard T
纳米医学作为一个领域已经从基于纳米颗粒的药物递送系统的早期成功中出现，特别是用于治疗癌症，以及过去十年在纳米和生物技术方面取得的进展。基于纳米颗粒的药物递送系统有效的先决条件是药物有效载荷在靶位点释放。已经提出了大量的药物释放策略，其可以被分类到某些领域。迄今为止最简单和最成功的策略，可能是由于相对简单，是基于利用药物的某些物理化学特性，以获得在癌部位积累后从制剂中缓慢渗漏的药物。然而，这种策略只适用于相对较小范围的药物，不能应用于生物制品。因此，许多先进的药物释放策略进行了研究。这样的策略包括利用热、光和超声敏感系统，特别是pH敏感系统，其中内体中的较低pH诱导药物释放。非常令人感兴趣的是酶敏感系统，其中过度表达的疾病相关酶被用来触发药物释放。基于酶的策略特别有趣，因为它们不需要肿瘤定位的先验知识。这篇综述的基础是评价目前的药物递送策略的现状，重点是由疾病相关酶引发的药物释放。我们仅限于回顾脂质体领域，但这些概念和结论对基于聚合物的系统同样重要。
Nanomedicine as a field has emerged from the early success of nanoparticle-based drug delivery systems, in particular for treatment of cancer, and the advances made in nano- and biotechnology over the past decade. A prerequisite for nanoparticle-based drug delivery systems to be effective is that the drug payload is released at the target site. A large number of drug release strategies have been proposed that can be classified into certain areas. The simplest and most successful strategy so far, probably due to relative simplicity, is based on utilizing certain physico-chemical characteristics of drugs to obtain a slow drug leakage from the formulations after accumulation in the cancerous site. However, this strategy is only applicable to a relatively small range of drugs and cannot be applied to biologicals. Many advanced drug release strategies have therefore been investigated. Such strategies include utilization of heat, light and ultrasound sensitive systems and in particular pH sensitive systems where the lower pH in endosomes induces drug release. Highly interesting are enzyme sensitive systems where over-expressed disease-associated enzymes are utilized to trigger drug release. The enzyme-based strategies are particularly interesting as they require no prior knowledge of the tumour localization. The basis of this review is an evaluation of the current status of drug delivery strategies focused on triggered drug release by disease-associated enzymes. We limit ourselves to reviewing the liposome field, but the concepts and conclusions are equally important for polymer-based systems.
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影响因子：
15
作者：
Elegbede AI;Banerjee J;Hanson AJ;Tobwala S;Ganguli B;Wang R;Lu X;Srivastava DK;Mallik S
通讯作者：
Mallik S
影响因子：
3.4
作者：
ALLEN, TM;BRANDEIS, E;ZALIPSKY, S
通讯作者：
ZALIPSKY, S
DOI：
10.1016/s0360-3016(96)00389-6
发表时间：
1996-12-01
影响因子：
7
作者：
Gaber, MH;Wu, NZ;Papahadjopoulos, D
通讯作者：
Papahadjopoulos, D
DOI：
10.1053/ejso.2001.1134
发表时间：
2001-09-01
期刊：
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
影响因子：
--
作者：
Edhemovic, I;Snoj, M;Golouh, R
通讯作者：
Golouh, R
影响因子：
3.7
作者：
Emanuel, N;Kedar, E;Barenholz, Y
通讯作者：
Barenholz, Y