Hypertriglyceridemia in Newly Diagnosed Acute Promyelocytic Leukemia.
Hypertriglyceridemia in Newly Diagnosed Acute Promyelocytic Leukemia.
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DOI：
10.3389/fonc.2020.577796
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发表时间：
2020
影响因子：
4.7
通讯作者：
Zhu HH
中科院分区：
文献类型：
--
作者：
Sun J;Lou Y;Zhu J;Shen H;Zhou D;Zhu L;Yang X;Xie M;Li L;Huang X;Zhu M;Zheng Y;Xie W;Ye X;Jin J;Zhu HH
本回顾性研究的主要目的是调查急性早幼粒细胞白血病（APL）患者的血脂谱和动力学。我们分析了402例初诊APL患者和201例非APL急性髓系白血病患者（作为对照）。APL患者和非APL患者的高甘油三酯血症发生率分别为55.82%和28.4%（p = 0.0003）。APL患者的甘油三酯、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的初始水平均高于对照组（均p < 0.0001）。在APL患者中，在用全反式维甲酸和砷诱导治疗期间，甘油三酯水平显著升高。多因素分析显示，年龄、超重（体重指数≥25）和APL是所有患者治疗前高血脂的独立危险因素。高甘油三酯水平与APL患者的无病生存率或总生存率无显著相关。总之，在本研究中，APL患者治疗前甘油三酯水平显著升高，诱导治疗期间甘油三酯水平升高，但对生存期无显著相应影响。
The primary aim of the present retrospective study was to investigate lipid profiles and kinetics in acute promyelocytic leukemia (APL) patients. We analyzed 402 newly diagnosed APL patients and 201 non-APL patients with acute myeloid leukemia (as control). Incidence of hypertriglyceridemia in APL patients and non-APL patients was 55.82% and 28.4% (p = 0.0003). The initial levels of triglycerides, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were higher in APL patients than in control (all p < 0.0001). In APL patients, triglyceride levels were significantly increased during induction treatment with all-trans retinoic acid and arsenic. Multivariable analysis showed that age, being overweight (body mass index ≥25) and APL were independent risk factors for hypertriglyceridemia in all patients before treatment. High triglyceride levels were not significantly associated with disease-free survival or overall survival in the APL patients. In summary, in the current study triglyceride levels were significantly elevated in APL patients before treatment, and they increased during induction treatment, but there were no significant corresponding effects on survival.
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影响因子：
120.7
作者：
Carroll, Margaret D.;Kit, Brian K.;Mussolino, Michael E.
通讯作者：
Mussolino, Michael E.
影响因子：
16.6
作者：
Martin-Martin, Natalia;Piva, Marco;Carracedo, Arkaitz
通讯作者：
Carracedo, Arkaitz
影响因子：
15.9
作者：
Carracedo, Arkaitz;Weiss, Dror;Pandolfi, Pier P.
通讯作者：
Pandolfi, Pier P.
影响因子：
20.3
作者：
Breccia, Massimo;Mazzarella, Luca;Lo-Coco, Francesco
通讯作者：
Lo-Coco, Francesco
影响因子：
64.5
作者：
KLIEWER, SA;LENHARD, JM;LEHMANN, JM
通讯作者：
LEHMANN, JM