Spatial receptive field organization of multisensory neurons and its impact on multisensory interactions.
Spatial receptive field organization of multisensory neurons and its impact on multisensory interactions.
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DOI：
10.1016/j.heares.2009.08.003
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发表时间：
2009-12
期刊：
影响因子：
2.8
通讯作者：
Wallace, Mark T.
中科院分区：
文献类型：
--
作者：
Krueger, Juliane;Royal, David W.;Fister, Matthew C.;Wallace, Mark T.
以往的工作已经证实，大脑皮层多感觉神经元的空间感受野(SRF)具有显著的异质性，SRF的结构在感觉反应和多感觉整合能力中起着重要的决定性作用。这一贡献的最初部分用于回顾这些发现，通过突出猫前外胚层沟(AES)的工作，详细描述了皮质多感官群体中SRF组织的关键特征。此外，我们最近进行了平行研究，旨在研究多感官研究的经典模型-猫上丘(SC)中的SRF结构，我们在这里介绍了SC的一些初步观察结果。对单个SC神经元的检查发现，它们的单感觉(即视觉和听觉)SRF以及这些单感觉SRF与多感觉SRF之间存在显著的相似之处。尽管单个神经元有这些相似之处，但不同的SC神经元具有从单个最活跃区域(热点)到多个空间离散热点的SRF。与皮质多感觉神经元相似，SC神经元的相互作用轮廓与SRF构筑密切相关，遵循逆效应原理。因此，在视觉和听觉刺激效果较弱的SRF位置，通常可以看到大的、往往是超加性的多感觉反应增强。相反，在刺激高度有效的SRF位置，可以看到亚加性交互作用。尽管皮层和皮质下多感觉回路具有独特的功能特征，但我们的结果表明，SRF微结构和综合能力之间存在很强的机械相互关系。
Previous work has established that the spatial receptive fields (SRFs) of multisensory neurons in the cerebral cortex are strikingly heterogeneous, and that SRF architecture plays an important deterministic role in sensory responsiveness and multisensory integrative capacities. The initial part of this contribution serves to review these findings detailing the key features of SRF organization in cortical multisensory populations by highlighting work from the cat anterior ectosylvian sulcus (AES). In addition, we have recently conducted parallel studies designed to examine SRF architecture in the classic model for multisensory studies, the cat superior colliculus (SC), and we present some of the preliminary observations from the SC here. An examination of individual SC neurons revealed marked similarities between their unisensory (i.e., visual and auditory) SRFs, as well as between these unisensory SRFs and the multisensory SRF. Despite these similarities within individual neurons, different SC neurons had SRFs that ranged from a single area of greatest activation (hot spot) to multiple and spatially discrete hot spots. Similar to cortical multisensory neurons, the interactive profile of SC neurons was correlated strongly to SRF architecture, closely following the principle of inverse effectiveness. Thus, large and often superadditive multisensory response enhancements were typically seen at SRF locations where visual and auditory stimuli were weakly effective. Conversely, subadditive interactions were seen at SRF locations where stimuli were highly effective. Despite the unique functions characteristic of cortical and subcortical multisensory circuits, our results suggest a strong mechanistic interrelationship between SRF microarchitecture and integrative capacity.
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