Experience with moving visual stimuli drives the early development of cortical direction selectivity.
Experience with moving visual stimuli drives the early development of cortical direction selectivity.
复制标题
DOI：
10.1038/nature07417
复制
发表时间：
2008-12-18
期刊：
影响因子：
64.8
通讯作者：
Fitzpatrick, David
中科院分区：
文献类型：
--
作者：
Li, Ye;Van Hooser, Stephen D.;Mazurek, Mark;White, Leonard E.;Fitzpatrick, David
视觉的开始发生在视觉皮层的神经回路不成熟的时候，缺乏完整的连接和定义功能成熟的反应选择性。方向选择性反应特别容易受到早期视觉剥夺的影响，但刺激驱动的神经活动如何指导皮层方向选择性的出现仍不清楚。为了探索这个问题，我们开发了一种新的运动训练范式，使我们能够监测经验对视觉naïve雪貂方向选择反应发展的影响。利用固有信号成像技术，我们发现单一运动轴的训练诱导了定向柱的快速出现，这些定向柱局限于被训练刺激优先激活的皮层区域。利用双光子钙成像技术，我们发现视觉naïve动物的单个神经元表现出较弱的方向偏好，并且在方向偏好的空间组织中缺乏较强的局部相干性，这在成熟动物中很明显。运动刺激训练，而非闪烁刺激训练，加强了单个神经元的方向选择反应，并优先扭转偏离其邻居的神经元的方向偏差。这两种效应都增加了局部相干性。我们的结论是，早期对移动视觉刺激的体验推动了视觉皮层中方向选择反应的快速出现。
The onset of vision occurs when neural circuits in the visual cortex are immature, lacking the full complement of connections and the response selectivity that defines functional maturity. Direction selective responses are particularly vulnerable to the effects of early visual deprivation, but how stimulus driven neural activity guides the emergence of cortical direction selectivity remains unclear. To explore this issue we developed a novel motion training paradigm that allowed us to monitor the impact of experience on the development of direction selective responses in visually naïve ferrets. Using intrinsic signal imaging techniques we found that training with a single axis of motion induced the rapid emergence of direction columns that were confined to cortical regions preferentially activated by the training stimulus. Using 2-photon calcium imaging techniques, we found that single neurons in visually naïve animals exhibited weak directional biases and lacked the strong local coherence in the spatial organization of direction preference that was evident in mature animals. Training with a moving stimulus, but not with a flashed stimulus, strengthened the direction selective responses of individual neurons and preferentially reversed the direction biases of neurons that deviated from their neighbors. Both effects contributed to an increase in local coherence. We conclude that early experience with moving visual stimuli drives the rapid emergence of direction selective responses in visual cortex.
登录
查看更多内容
影响因子：
25
作者：
Song, S;Miller, KD;Abbott, LF
通讯作者：
Abbott, LF
影响因子：
16.2
作者：
Meliza, CD;Dan, Y
通讯作者：
Dan, Y
影响因子：
64.8
作者：
Weliky, M;Bosking, WH;Fitzpatrick, D
通讯作者：
Fitzpatrick, D
影响因子：
2.5
作者：
Cai, DQ;DeAngelis, GC;Freeman, RD
通讯作者：
Freeman, RD
影响因子：
25
作者：
Li, Y;Fitzpatrick, D;White, LE
通讯作者：
White, LE