Clinical perspectives on ischemic stroke.

Clinical perspectives on ischemic stroke.
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DOI:
10.1016/j.expneurol.2021.113599
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发表时间:
2021-04
影响因子:
5.3
通讯作者:
Yenari MA
Yenari MA
中科院分区:
医学2区
文献类型:
--
作者:
Mizuma A;Yenari MA

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在过去的几年里,急性中风的治疗方法有所改善,但很大程度上仅限于血运重建策略。神经保护的话题,或者限制脑组织损伤甚至逆转它的策略,仍然是难以捉摸的。因此,脑卒中管理的临床重点是预防。神经保护疗法缺乏临床转化,在实验室中显示出希望,部分原因可能是由于历史上对大多数中风患者所遭受的合并症的忽视。随着更多包含一种或多种相关合并症的中风模型的出现,可能有可能确定有效的治疗方法,并可能转化为临床层面的新治疗方法。同时,我们回顾了脑卒中患者的合并症、脑卒中危险因素的改变以及临床上可用的急性脑卒中治疗方法。
Treatments for acute stroke have improved over the past years, but have largely been limited to revascularization strategies. The topic of neuroprotection, or strategies to limit brain tissue damage or even reverse it, has remained elusive. Thus, the clinical mainstays for stroke management have focused on prevention. The lack of clinical translation of neuroprotective therapies which have shown promise in the laboratory may, in part, be due to a historic inattention to comorbidities suffered by a majority of stroke patients. With the advent of more stroke models that include one or more relevant comorbidities, it may be possible to identify effective treatments that may translate into new treatments at the clinical level. In the meantime, we review comorbidities in stroke patients, modification of stroke risk factors and available acute stroke treatments in the clinic.
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