Minireview: Neuroprotective Effects of Estrogen-New Insights into Mechanisms of Action.
Minireview: Neuroprotective Effects of Estrogen-New Insights into Mechanisms of Action.
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小评论：雌激素的神经保护作用——作用机制的新见解。
作者：
P. Wise;D. Dubal;M. Wilson;S. Rau;Martina Bo Ttner
越来越多的证据清楚地表明，雌二醇是成年人体内一种强大的神经保护和神经营养因子：它影响记忆和认知，降低风险，推迟阿尔茨海默病等神经系统疾病的发生，并减轻脑血管中风和神经创伤等脑损伤导致的细胞死亡程度。因此，雌二醇似乎在两个水平上起作用：1)它降低疾病或伤害的风险；和/或2)它通过抑制神经毒性刺激本身或增加大脑对给定伤害的弹性来减少伤害的程度。在过去的一个世纪里，女性的平均寿命大幅增加，而更年期的时间基本上保持不变。因此，更多的女性将比以往任何时候都更多地生活在绝经后低雌激素状态下。显然，这对我们理解雌二醇在什么情况下发挥保护作用和保护人体健康是至关重要的。
An accumulating body of evidence clearly establishes that estradiol is a potent neuroprotective and neurotrophic factor in the adult: it influences memory and cognition, decreases the risk and delays the onset of neurological diseases such as Alzheimer’s disease, and attenuates the extent of cell death that results from brain injuries such as cerebrovascular stroke and neurotrauma. Thus, estradiol appears to act at two levels: 1) it decreases the risk of disease or injury; and/or 2) it decreases the extent of injury incurred by suppressing the neurotoxic stimulus itself or increasing the resilience of the brain to a given injury. During the past century, the average life span of women has increased dramatically, whereas the time of the menopause has remained essentially constant. Thus, more women will live a larger fraction of their lives in a postmenopausal, hypoestrogenic state than ever before. Clearly, it is critical for us understand the circumstances under which estradiol exerts protective actions a...
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影响因子：
4.8
作者：
J. Watters;J. S. Campbell;M. Cunningham;E. Krebs;D. Dorsa
通讯作者：
J. Watters;J. S. Campbell;M. Cunningham;E. Krebs;D. Dorsa
DOI：
10.1042/bj3301097
发表时间：
1998-03
期刊：
The Biochemical journal
影响因子：
--
作者：
A. K. Morey;M. Razandi;A. Pedram;R. Hu;Bruce A. Prins;E. Levin
通讯作者：
A. K. Morey;M. Razandi;A. Pedram;R. Hu;Bruce A. Prins;E. Levin
影响因子：
4.8
作者：
Yue Zhou;J. Watters;D. Dorsa
通讯作者：
Yue Zhou;J. Watters;D. Dorsa
影响因子：
8.3
作者：
Yang, SH;Shi, J;Simpkins, JW
通讯作者：
Simpkins, JW
影响因子：
4.8
作者：
D. Stone;Yubei Song;Christopher P. Anderson;K. Krohn;C. Finch;I. Rozovsky
通讯作者：
D. Stone;Yubei Song;Christopher P. Anderson;K. Krohn;C. Finch;I. Rozovsky