Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration.
Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration.
复制标题
米诺环素可减少神经炎症，但不能改善神经变性小鼠模型中的神经元损失。
DOI：
10.1038/srep10535
复制
发表时间：
2015-05-22
影响因子：
4.6
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Cheng S;Hou J;Zhang C;Xu C;Wang L;Zou X;Yu H;Shi Y;Yin Z;Chen G
二甲胺四环素是一种广谱四环素类抗生素。许多临床前研究表明，米诺环素在各种神经系统疾病的动物模型中表现出神经保护作用。然而，二甲胺四环素是否有效防止神经元丢失仍不清楚。为了系统地评估其效果，二甲胺四环素用于治疗Dicer条件敲除（cKO）小鼠，这些小鼠表现出与年龄相关的神经元丢失。在发生神经炎症和神经退行性变之前给药，治疗持续2个月。二甲胺环素治疗的Dicer cKO小鼠的炎症标志物，包括胶质纤维酸性蛋白（GFAP）、离子钙结合适配器分子1 （Iba1）和白细胞介素6 （IL6）水平显著降低。相比之下，Dicer cKO小鼠的神经元标记物水平和凋亡细胞总数不受药物影响。总之，米诺环素对神经炎症的抑制不足以防止神经元丢失和细胞凋亡。
Minocycline is a broad-spectrum tetracycline antibiotic. A number of preclinical studies have shown that minocycline exhibits neuroprotective effects in various animal models of neurological diseases. However, it remained unknown whether minocycline is effective to prevent neuron loss. To systematically evaluate its effects, minocycline was used to treat Dicer conditional knockout (cKO) mice which display age-related neuron loss. The drug was given to mutant mice prior to the occurrence of neuroinflammation and neurodegeneration, and the treatment had lasted 2 months. Levels of inflammation markers, including glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule1 (Iba1) and interleukin6 (IL6), were significantly reduced in minocycline-treated Dicer cKO mice. In contrast, levels of neuronal markers and the total number of apoptotic cells in Dicer cKO mice were not affected by the drug. In summary, inhibition of neuroinflammation by minocycline is insufficient to prevent neuron loss and apoptosis.
登录
查看更多内容
影响因子：
2.5
作者：
Kawase-Koga, Yoko;Otaegi, Gaizka;Sun, Tao
通讯作者：
Sun, Tao
影响因子：
82.9
作者：
Chen, M;Ona, VO;Friedlander, RM
通讯作者：
Friedlander, RM
影响因子：
9.3
作者：
Kay, Graham W.;Palmer, David N.
通讯作者：
Palmer, David N.
影响因子：
56.9
作者：
Kim, Jongpil;Inoue, Keiichi;Abeliovich, Asa
通讯作者：
Abeliovich, Asa
DOI：
10.1073/pnas.0710263105
发表时间：
2008-04-29
影响因子：
11.1
作者：
Hebert, Sebastien S.;Horre, Katrien;De Strooper, Bart
通讯作者：
De Strooper, Bart