Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.
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DOI：
10.1016/j.immuni.2012.12.001
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发表时间：
2013-01-24
期刊：
影响因子：
32.4
通讯作者：
Jung S
中科院分区：
文献类型：
--
作者：
Yona S;Kim KW;Wolf Y;Mildner A;Varol D;Breker M;Strauss-Ayali D;Viukov S;Guilliams M;Misharin A;Hume DA;Perlman H;Malissen B;Zelzer E;Jung S
单核吞噬细胞，包括单核细胞、巨噬细胞和树突状细胞，有助于组织完整性以及先天性和适应性免疫防御。劳动分工的新证据表明，对这些细胞的操纵可能具有治疗潜力。然而，个体群体的具体个体发育和细胞网络的整体功能组织尚未明确定义。在这里，我们报告了利用组成型和条件性 CX3CR1 启动子驱动的 Cre 重组酶表达对小鼠单核细胞和巨噬细胞区室进行命运图谱研究。我们已经证明，主要的组织驻留巨噬细胞群，包括肝库普弗细胞、肺泡、脾和腹膜巨噬细胞，在出生前就已形成，并在成年后独立于血单核细胞的补充而维持自身。此外，我们已经确定，短命的 Ly6C+ 单核细胞构成血液驻留 Ly6C− 细胞的必然稳态前体，并且 Ly6C+ 血液单核细胞的丰度动态控制其后代的循环寿命。
Mononuclear phagocytes, including monocytes, macrophages and dendritic cells, contribute to tissue integrity, as well as innate and adaptive immune defense. Emerging evidence for labour division indicates that manipulation of these cells could bear therapeutic potential. However, specific ontogenies of individual populations and the overall functional organisation of the cellular network are not well-defined. Here we report a fate mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX3CR1 promoter-driven Cre recombinase expression. We have demonstrated that major tissue resident macrophage populations, including liver Kupffer cells, lung alveolar, splenic and peritoneal macrophages, are established prior to birth and maintain themselves subsequently during adulthood independent of replenishment by blood monocytes. Furthermore, we have established that the short-lived Ly6C+ monocytes constitute obligatory steady state precursors of blood-resident Ly6C− cells and that the abundance of Ly6C+ blood monocytes dynamically controls the circulation life span of their progeny.
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DOI：
10.1084/jem.148.1.1
发表时间：
1978-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Crofton RW;Diesselhoff-den Dulk MM;van Furth R
通讯作者：
van Furth R
DOI：
10.1084/jem.20120340
发表时间：
2012-06-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hoeffel G;Wang Y;Greter M;See P;Teo P;Malleret B;Leboeuf M;Low D;Oller G;Almeida F;Choy SH;Grisotto M;Renia L;Conway SJ;Stanley ER;Chan JK;Ng LG;Samokhvalov IM;Merad M;Ginhoux F
通讯作者：
Ginhoux F
影响因子：
5.3
作者：
Jung, S;Aliberti, J;Littman, DR
通讯作者：
Littman, DR
影响因子：
--
作者：
Bruehl, Hilke;Cihak, Josef;Mack, Matthias
通讯作者：
Mack, Matthias
影响因子：
25
作者：
Ajami, Bahareh;Bennett, Jami L.;Rossi, Fabio M. V.
通讯作者：
Rossi, Fabio M. V.