Digital subtraction high-frame-rate echocardiography in detecting delayed onset of regional left ventricular relaxation in ischemic heart disease.
Digital subtraction high-frame-rate echocardiography in detecting delayed onset of regional left ventricular relaxation in ischemic heart disease.
复制标题
数字减影高帧率超声心动图检测缺血性心脏病中局部左心室舒张延迟发作。
DOI：
10.1161/01.cir.91.2.304
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发表时间：
1995
期刊：
影响因子：
37.8
通讯作者：
T. Kamada
中科院分区：
文献类型：
--
作者：
H. Kondo;T. Masuyama;K. Ishihara;T. Mano;Kazuhiro Yamamoto;J. Naito;R. Nagano;S. Kishimoto;J. Tanouchi;M. Hori;H. Takeda;M. Inoue;T. Kamada
BACKGROUND
Because left ventricular (LV) diastolic function is impaired before systolic function in patients with ischemic heart disease and because ischemic heart disease is constituted of regional rather than global abnormalities of the left ventricle, measures of LV regional diastolic dysfunction, if possible, should provide the most sensitive assessment of the coronary involved region. The objectives of this study are to clarify whether high-frame-rate two-dimensional echocardiography, combined with digital subtraction image processing, may be used to visualize regional LV relaxation abnormalities in patients with ischemic heart disease and to clarify whether this technique provides a measure for the noninvasive assessment of the coronary involved region.
METHOD AND RESULTS
In 30 normal subjects and 59 patients with ischemic heart disease, two-dimensional echocardiograms obtained at a rate of 60 frames per second were provided on line for digital subtraction analysis, with which digitized images were continuously subtracted on a frame-by-frame basis. The subtracted images were analyzed to determine the onset of the segmental outward motion of the LV wall in early diastole in each of 16 segments per subject. Regional relaxation index, defined as the interval from the second heart sound to the onset of outward wall motion, was significantly prolonged in the coronary involved segments compared with the normal segments (36.3 +/- 18.0 versus 101.2 +/- 34.0 ms, P < .01). The prolongation in the regional relaxation index was observed even in the coronary involved segments without reduction in systolic wall motion. When a cutoff level of 50.0 ms was used, coronary involved segments could be distinguished from normal or border segments with a sensitivity of 92% and a specificity of 81%.
CONCLUSIONS
Digital subtraction high-frame-rate echocardiography may be used to visualize regional LV relaxation abnormalities in patients with ischemic heart disease. The time interval from the second heart sound to the onset of the segmental outward motion of the LV wall (regional relaxation index) obtained with this technique provides a noninvasive and accurate measure for assessing coronary involved regions.
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DOI：
10.1152/ajpheart.1989.256.1.h222
发表时间：
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期刊：
The American journal of physiology
影响因子：
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作者：
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DOI：
10.1016/0002-9149(90)91424-5
发表时间：
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期刊：
The American journal of cardiology
影响因子：
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作者：
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