Impact of child malnutrition on the specific anti-Plasmodium falciparum antibody response.
Impact of child malnutrition on the specific anti-Plasmodium falciparum antibody response.
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DOI：
10.1186/1475-2875-8-116
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发表时间：
2009-06-02
期刊：
影响因子：
3
通讯作者：
Remoué F
中科院分区：
文献类型：
--
作者：
Fillol F;Sarr JB;Boulanger D;Cisse B;Sokhna C;Riveau G;Simondon KB;Remoué F
在撒哈拉以南非洲，学龄前儿童是最易受疟疾和营养不良影响的人群。人们普遍认为，营养不良会损害免疫功能，导致感染风险增加。然而，很少有研究调查疟疾、营养不良和特异性免疫之间的关系。在本研究中，抗恶性疟原虫IgG抗体（Ab）的反应进行了评估，根据儿童营养不良的类型。人体测量评估和血液样本采集过程中进行了横断面调查，包括农村塞内加尔学龄前儿童。这项跨部门调查是在2003年7月雨季开始时进行的。营养不良被定义为发育迟缓（身高-年龄比z分数<-2）或消瘦（体重-身高比z分数<-2）。7月对所有营养不良儿童进行了分析（n = 161，发育不良，n = 142或消瘦，n = 19），与营养良好的对照组配对。ELISA法检测患儿血清中对恶性疟原虫全提取物（抗原）的IgG抗体反应。营养不良儿童的抗疟免疫应答者和特异性IgG抗体水平均显著低于对照组。根据营养不良的类型，浪费的儿童和发育迟缓的儿童提出了较低的特异性IgG抗体反应比各自的控制，但这种差异是显着的，只有在发育迟缓的儿童（P = 0.026）。与对照组相比，严重发育迟缓儿童（HAZ ≤ -2.5）的特异性Ab应答下调似乎可以解释（P = 0.03），而在轻度发育迟缓儿童中未观察到显著差异（-2.5 < HAZ <-2.0）。儿童营养不良对特异性抗恶性疟原虫抗体反应的影响似乎与感染强度无关。儿童营养不良，特别是发育迟缓，可能会下调抗恶性疟原虫抗体反应，无论是在免疫应答者的患病率和特异性IgG抗体水平。这项研究提供了营养不良对特定抗疟疾免疫反应的影响的进一步证据，并指出在疟疾流行病学研究和疫苗试验中考虑儿童营养不良的重要性。
In sub-Saharan Africa, preschool children represent the population most vulnerable to malaria and malnutrition. It is widely recognized that malnutrition compromises the immune function, resulting in higher risk of infection. However, very few studies have investigated the relationship between malaria, malnutrition and specific immunity. In the present study, the anti-Plasmodium falciparum IgG antibody (Ab) response was evaluated in children according to the type of malnutrition. Anthropometric assessment and blood sample collection were carried out during a cross-sectional survey including rural Senegalese preschool children. This cross-sectional survey was conducted in July 2003 at the onset of the rainy season. Malnutrition was defined as stunting (height-for-age <-2 z-scores) or wasting (weight-for-height <-2 z-scores). The analysis was performed on all malnourished children in July (n = 161, either stunted, n = 142 or wasted, n = 19), pair-matched to well-nourished controls. The IgG Ab response to P. falciparum whole extracts (schizont antigens) was assessed by ELISA in sera of the included children. Both the prevalence of anti-malarial immune responders and specific IgG Ab levels were significantly lower in malnourished children than in controls. Depending on the type of malnutrition, wasted children and stunted children presented a lower specific IgG Ab response than their respective controls, but this difference was significant only in stunted children (P = 0.026). This down-regulation of the specific Ab response seemed to be explained by severely stunted children (HAZ ≤ -2.5) compared to their controls (P = 0.03), while no significant difference was observed in mildly stunted children (-2.5 < HAZ <-2.0). The influence of child malnutrition on the specific anti-P. falciparum Ab response appeared to be independent of the intensity of infection. Child malnutrition, and particularly stunting, may down-regulate the anti-P. falciparum Ab response, both in terms of prevalence of immune responders and specific IgG Ab levels. This study provides further evidence for the influence of malnutrition on the specific anti-malarial immune response and points to the importance of taking into account child malnutrition in malaria epidemiological studies and vaccine trials.
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影响因子：
3.3
作者：
Müller, O;Garenne, M;Becher, H
通讯作者：
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影响因子：
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作者：
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