Decreased serum levels of thrombospondin‐1 in female depressed patients
Decreased serum levels of thrombospondin‐1 in female depressed patients
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降低女性抑郁症患者血清血小板反应蛋白-1水平
DOI：
10.1002/npr2.12088
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发表时间：
2019
影响因子：
2.5
通讯作者：
Takebayashi Minoru
中科院分区：
文献类型：
--
作者：
Okada‐Tsuchioka Mami;Omori Wataru;Kajitani Naoto;Shibasaki Chiyo;Itagaki Kei;Takebayashi Minoru
目的血小板反应蛋白-1（TSP-1）是一种星形胶质细胞源性突触发生相关因子。先前报告称，在大鼠海马中，慢性电惊厥发作（电惊厥治疗（ECT）的一种模型）可使其增加。本研究旨在探讨血清TSP-1水平是否与抑郁症和ECT有关。方法采用TSP-1 ELISA法检测36例重度抑郁症（MDD）患者和36例年龄、性别匹配的健康对照者血清TSP-1水平。MDD患者根据精神疾病诊断和统计手册-IV-TR进行诊断，并接受ECT。还分析了MDD患者ECT前后的血清TSP-1水平。使用汉密尔顿抑郁症评定量表进行症状评估。ResultsSerum TSP-1水平显示女性MDD患者特异性显著降低。然而，TSP-1并没有改变前和后ECT，没有相关的症状，也不受剂量的抗抑郁药。ConclusionSerum TSP-1是一个可能的女性特有的因素，反映抑郁的特质，但不是状态。
AimThrombospondin‐1 (TSP‐1) is an astrocyte‐derived synaptogenesis‐related factor. It was previously reported to be increased by chronic treatment of electroconvulsive seizure, a model of electroconvulsive therapy (ECT), in rat hippocampus. The aim of this study was to examine whether serum levels of TSP‐1 are associated with depression and ECT.MethodsSerum TSP‐1 levels of major depressive disorder (MDD) patients (n = 36) and age‐ and gender‐matched healthy controls (n = 36) were measured by TSP‐1 ELISA. MDD patients were diagnosed according to theDiagnostics and Statistical Manual of Mental Disorders‐IV‐TR and underwent ECT. MDD patients were also analyzed for serum TSP‐1 levels pre‐ and post‐ECT. Evaluation of symptoms was obtained using the Hamilton Rating Scale for Depression.ResultsSerum TSP‐1 levels showed significant decreases specific to female MDD patients. However, TSP‐1 did not change pre‐ and post‐ECT, did not correlate with symptoms, nor was not affected by the dose of antidepressants.ConclusionSerum TSP‐1 is a possible female‐specific factor that reflects depressive trait, but not state.
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影响因子：
15.9
作者：
Lawler, J;Sunday, M;Hynes, RO
通讯作者：
Hynes, RO
抑郁症受试者验尸后海马中突触和谷氨酸相关基因的表达改变。
DOI：
10.1017/s1461145712000016
发表时间：
2013-02
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
Duric V;Banasr M;Stockmeier CA;Simen AA;Newton SS;Overholser JC;Jurjus GJ;Dieter L;Duman RS
通讯作者：
Duman RS
影响因子：
6.4
作者：
Hyder SM;Liang Y;Wu J
通讯作者：
Wu J
DOI：
10.1073/pnas.95.22.13290
发表时间：
1998-10-27
影响因子：
11.1
作者：
Öngür, D;Drevets, WC;Price, JL
通讯作者：
Price, JL