The Insulin-like Growth Factor Signaling Pathway in Breast Cancer: An Elusive Therapeutic Target.
The Insulin-like Growth Factor Signaling Pathway in Breast Cancer: An Elusive Therapeutic Target.
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DOI：
10.3390/life12121992
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发表时间：
2022-11-29
期刊：
影响因子：
3.2
通讯作者：
Shaw, Leslie M.
中科院分区：
文献类型：
--
作者：
Lee, Ji-Sun;Tocheny, Claire E.;Shaw, Leslie M.
关键词：
在这篇综述中，我们提供了一个概述的胰岛素样生长因子（IGF）信号通路在乳腺癌中的作用，并讨论其作为治疗靶点的潜力。IGF途径配体IGF-1和IGF-2及其受体（主要是IGF-1 R）对正常乳腺生物学很重要，其表达和功能失调通过激活下游信号效应子（通常以亚型依赖性方式）驱动乳腺癌风险和进展。IGF信号通路还涉及对当前治疗策略的抗性，包括ER和HER 2靶向药物。不幸的是，由于许多因素，靶向IGF信号传导以治疗乳腺癌的努力一直不成功，最显著的是破坏IGF信号传导对正常葡萄糖代谢的不利影响。我们在这里强调最近的发现，为继续努力靶向IGF信号传导治疗乳腺癌患者提供了热情。
In this review, we provide an overview of the role of the insulin-like growth factor (IGF) signaling pathway in breast cancer and discuss its potential as a therapeutic target. The IGF pathway ligands, IGF-1 and IGF-2, and their receptors, primarily IGF-1R, are important for normal mammary gland biology, and dysregulation of their expression and function drives breast cancer risk and progression through activation of downstream signaling effectors, often in a subtype-dependent manner. The IGF signaling pathway has also been implicated in resistance to current therapeutic strategies, including ER and HER2 targeting drugs. Unfortunately, efforts to target IGF signaling for the treatment of breast cancer have been unsuccessful, due to a number of factors, most significantly the adverse effects of disrupting IGF signaling on normal glucose metabolism. We highlight here the recent discoveries that provide enthusiasm for continuing efforts to target IGF signaling for the treatment of breast cancer patients.
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DOI：
10.1186/s13058-017-0923-5
发表时间：
2017-12-06
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
De Francesco EM;Sims AH;Maggiolini M;Sotgia F;Lisanti MP;Clarke RB
通讯作者：
Clarke RB
影响因子：
64.5
作者：
BAKER, J;LIU, JP;EFSTRATIADIS, A
通讯作者：
EFSTRATIADIS, A
影响因子：
11.8
作者：
Brisken, C;Ayyannan, A;Heineman, A
通讯作者：
Heineman, A
影响因子：
8.2
作者：
Björnholm, M;He, AR;Zierath, JR
通讯作者：
Zierath, JR
影响因子：
5.7
作者：
Carboni, Joan M.;Wittman, Mark;Gottardis, Marco M.
通讯作者：
Gottardis, Marco M.