Benchmark experimental data set and assessment of adsorption free energy for peptide-surface interactions.
Benchmark experimental data set and assessment of adsorption free energy for peptide-surface interactions.
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DOI：
10.1021/la8042186
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发表时间：
2009-05-19
期刊：
影响因子：
--
通讯作者：
Latour RA
中科院分区：
文献类型：
--
作者：
Wei Y;Latour RA
With the increasing interest in protein adsorption in fields ranging from bionanotechnology to biomedical engineering, there is a growing need to understand protein-surface interactions at a fundamental level, such as the interaction between individual amino acid residues of a protein and functional groups presented by a surface. However, relatively little data are available that experimentally provide a quantitative, comparative measure of these types of interactions. To address this deficiency, the objective of this study was to generate a database of experimentally measured standard state adsorption free energy (ΔGoads) values for a wide variety of amino acid residue-surface interactions using a host-guest peptide and alkanethiol self-assembled monolayers (SAMs) with polymer-like functionality as the model system. The host-guest amino acid sequence was synthesized in the form of TGTG-X-GTGT where G & T are glycine and threonine amino acid residues and X represents a variable residue. In this paper, we report ΔGoads values for the adsorption of twelve different types of the host-guest peptides on a set of nine different SAM surfaces, for a total of 108 peptide-surface systems. The ΔGoads values for these 108 peptide-surface combinations show clear trends in adsorption behavior that are dependent on both peptide composition and surface chemistry. These data provide a benchmark experimental data set from which fundamental interactions that govern peptide and protein adsorption behavior can be better understood and compared.
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影响因子：
3.9
作者：
Fears, Kenan P.;Creager, Stephen E.;Latour, Robert A.
通讯作者：
Latour, Robert A.
影响因子：
5.6
作者：
Ladokhin, AS;White, SH
通讯作者：
White, SH
影响因子：
3.9
作者：
Agashe, M;Raut, V;Latour, RA
通讯作者：
Latour, RA
影响因子：
14
作者：
Lee, SW;Laibinis, PE
通讯作者：
Laibinis, PE
影响因子：
4.9
作者：
Latour, Robert A.
通讯作者：
Latour, Robert A.