The incidence and mortality of yellow fever in Africa: a systematic review and meta-analysis.

The incidence and mortality of yellow fever in Africa: a systematic review and meta-analysis.
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DOI:
10.1186/s12879-021-06728-x
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发表时间:
2021-10-23
影响因子:
3.7
通讯作者:
Nyasulu PS
Nyasulu PS
中科院分区:
医学3区
文献类型:
--
作者:
Nwaiwu AU;Musekiwa A;Tamuzi JL;Sambala EZ;Nyasulu PS

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了解黄热病疫情的发生对于减少疾病负担的有针对性的干预和控制工作至关重要。我们评估了有关非洲黄热病发病率和死亡率的数据。计算机检索Cochrane图书馆、Scope us、MEDLINE、CINAHL、PubMed、Embase、Africa-wide和Web of Science数据库,检索期为1975年1月1日至2020年10月30日。两位作者独立地从纳入的研究中提取数据,并进行了荟萃分析。在确定的840项研究中,有12项研究被认为符合纳入条件。每100,000人口的黄热病发病率从尼日利亚的1例 、乌干达的3例、刚果民主共和国的13例、肯尼亚的27例、埃塞俄比亚的40例、冈比亚的46例、塞内加尔的1,267例和加纳的10,350例不等。与黄热病暴发有关的病死率从加纳的10%到尼日利亚的86%不等。死亡率从尼日利亚的0.1/10万到加纳的2200/100,000不等。黄热病发病率相当稳定;相比之下,在研究期间,非洲国家的死亡率差别很大。标准化的人口健康调查和监测以及准确的诊断措施对于及早识别、治疗和控制至关重要。网上版载有补充材料,可在10.1186/s12879-021-06728-x查阅。
Understanding the occurrence of yellow fever epidemics is critical for targeted interventions and control efforts to reduce the burden of disease. We assessed data on the yellow fever incidence and mortality rates in Africa. We searched the Cochrane Library, SCOPUS, MEDLINE, CINAHL, PubMed, Embase, Africa-wide and Web of science databases from 1 January 1975 to 30th October 2020. Two authors extracted data from included studies independently and conducted a meta-analysis. Of 840 studies identified, 12 studies were deemed eligible for inclusion. The incidence of yellow fever per 100,000 population ranged from < 1 case in Nigeria, < 3 cases in Uganda, 13 cases in Democratic Republic of the Congo, 27 cases in Kenya, 40 cases in Ethiopia, 46 cases in Gambia, 1267 cases in Senegal, and 10,350 cases in Ghana. Case fatality rate associated with yellow fever outbreaks ranged from 10% in Ghana to 86% in Nigeria. The mortality rate ranged from 0.1/100,000 in Nigeria to 2200/100,000 in Ghana. The yellow fever incidence rate is quite constant; in contrast, the fatality rates vary widely across African countries over the study period. Standardized demographic health surveys and surveillance as well as accurate diagnostic measures are essential for early recognition, treatment and control. The online version contains supplementary material available at 10.1186/s12879-021-06728-x.
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