African American Race is an Independent Risk Factor in Survival from Initially Diagnosed Localized Breast Cancer.
African American Race is an Independent Risk Factor in Survival from Initially Diagnosed Localized Breast Cancer.
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DOI：
10.7150/jca.16012
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发表时间：
2016
影响因子：
3.9
通讯作者：
Adam N
中科院分区：
文献类型：
--
作者：
Wieder R;Shafiq B;Adam N
背景：非裔美国人种族对局部乳腺癌的生存产生负面影响，但共变量因素混淆了这种影响。方法：对 1973 年至 2011 年监测、流行病学和最终结果 (SEER) 目录中的数据集进行分析，其中包括指定诊断为乳腺腺癌的患者、种族为白人或高加索人、黑人或非裔美国人、亚洲人、美洲印第安人或阿拉斯加原住民、夏威夷原住民或太平洋岛民、年龄、I、II 或 III 期、1、2 或 3 级、雌激素受体或孕激素受体阳性或消极，婚姻状况为单身、已婚、分居、离婚或丧偶，偏侧性为右或左。 Cox 比例风险回归模型用于确定生存风险比。应用卡方检验来确定在多变量 Cox 比例风险回归分析中发现显着的变量的相互依赖性。对具有相同特征（非裔美国人或白种人种除外）的患者的分层数据的细胞进行比较。结果：年龄、分期、年级、ER 和 PR 状态以及婚姻状况随种族和彼此之间显着共同变化。按单一协变量进行的分层表明，非洲裔美国人的生存风险比更差。由三个和四个协变量进行的分层表明，在具有足够数量值的大多数亚组中，非裔美国人的生存风险比更差。一些包含不良预后协变量的亚组的差异并未达到显着性，这表明种族效应可能会被额外的不良预后指标部分克服。结论：非裔美国人种族是乳腺癌生存的不良预后指标，独立于具有预后意义的 6 个相关协变量。
BACKGROUND: African American race negatively impacts survival from localized breast cancer but co-variable factors confound the impact. METHODS: Data sets were analyzed from the Surveillance, Epidemiology and End Results (SEER) directories from 1973 to 2011 consisting of patients with designated diagnosis of breast adenocarcinoma, race as White or Caucasian, Black or African American, Asian, American Indian or Alaskan Native, Native Hawaiian or Pacific Islander, age, stage I, II or III, grade 1, 2 or 3, estrogen receptor or progesterone receptor positive or negative, marital status as single, married, separated, divorced or widowed and laterality as right or left. The Cox Proportional Hazards Regression model was used to determine hazard ratios for survival. Chi square test was applied to determine the interdependence of variables found significant in the multivariable Cox Proportional Hazards Regression analysis. Cells with stratified data of patients with identical characteristics except African American or Caucasian race were compared. RESULTS: Age, stage, grade, ER and PR status and marital status significantly co-varied with race and with each other. Stratifications by single co-variables demonstrated worse hazard ratios for survival for African Americans. Stratification by three and four co-variables demonstrated worse hazard ratios for survival for African Americans in most subgroupings with sufficient numbers of values. Differences in some subgroupings containing poor prognostic co-variables did not reach significance, suggesting that race effects may be partly overcome by additional poor prognostic indicators. CONCLUSIONS: African American race is a poor prognostic indicator for survival from breast cancer independent of 6 associated co-variables with prognostic significance.
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影响因子：
168.9
作者：
DELAROCHEFORDIERE, A;ASSELAIN, B;FOURQUET, A
通讯作者：
FOURQUET, A
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