International versus national growth charts for identifying small and large-for-gestational age newborns: A population-based study in 15 European countries.
International versus national growth charts for identifying small and large-for-gestational age newborns: A population-based study in 15 European countries.
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DOI：
10.1016/j.lanepe.2021.100167
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Zeitlin J
中科院分区：
文献类型：
--
作者：
Hocquette A;Durox M;Wood R;Klungsøyr K;Szamotulska K;Berrut S;Rihs T;Kyprianou T;Sakkeus L;Lecomte A;Zile I;Alexander S;Klimont J;Barros H;Gatt M;Isakova J;Blondel B;Gissler M;Zeitlin J
为了告知正在进行的关于使用通用规定与国家宫内生长图表的争论，我们根据欧洲的国际和国家图表比较了小于胎龄儿和大于胎龄儿（SGA/LGA）的围产期死亡率。我们使用国际共生-21新生儿标准和基于定制图表方法的国家图表，将2010年和2014年来自15个国家（N = 1，475，457）的妊娠33至42周的单胎分娩分为SGA（出生体重<第10百分位数）和LGA（>第90百分位数）。我们使用多水平模型计算了死产、新生儿和延长围产期死亡率的性别调整优势比（aOR）。使用国家图表，所有国家的SGA和LGA患病率均接近10%，但根据国际图表，从北到南的梯度有所不同（分别为3.0%至10.1%和24.9%至8.0%）。与适合胎龄（阿加）的婴儿相比，两种图表均显示SGA的围产儿死亡风险增加（aOR[95%置信区间（CI）]=6.1 [5.6-6.7]）和根据国际图表从SGA重新分类为阿加的婴儿（2.7 [2.3-3.1]），但从阿加重新分类为LGA的婴儿降低（0.6 [0.4-0.7]）。死产和新生儿死亡的结果相似。在欧洲使用国际而不是国家图表可能导致生长受限的婴儿被重新分类为正常生长，而死亡风险低的婴儿可能被重新分类为过度生长。InfAct联合行动，CHAFEA赠款n° 801，553和EU/EFPIA创新药物倡议2联合承诺ConcePTION赠款n° 821，520。AH获得了EHESP的博士学位。
To inform the on-going debate about the use of universal prescriptive versus national intrauterine growth charts, we compared perinatal mortality for small and large-for-gestational-age (SGA/LGA) infants according to international and national charts in Europe. We classified singleton births from 33 to 42 weeks of gestation in 2010 and 2014 from 15 countries (N = 1,475,457) as SGA (birthweight <10th percentile) and LGA (>90th percentile) using the international Intergrowth-21st newborn standards and national charts based on the customised charts methodology. We computed sex-adjusted odds ratios (aOR) for stillbirth, neonatal and extended perinatal mortality by this classification using multilevel models. SGA and LGA prevalence using national charts were near 10% in all countries, but varied according to international charts with a north to south gradient (3.0% to 10.1% and 24.9% to 8.0%, respectively). Compared with appropriate for gestational age (AGA) infants by both charts, risk of perinatal mortality was increased for SGA by both charts (aOR[95% confidence interval (CI)]=6.1 [5.6–6.7]) and infants reclassified by international charts from SGA to AGA (2.7 [2.3–3.1]), but decreased for those reclassified from AGA to LGA (0.6 [0.4–0.7]). Results were similar for stillbirth and neonatal death. Using international instead of national charts in Europe could lead to growth restricted infants being reclassified as having normal growth, while infants with low risks of mortality could be reclassified as having excessive growth. InfAct Joint Action, CHAFEA Grant n°801,553 and EU/EFPIA Innovative Medicines Initiative 2 Joint Undertaking ConcePTION grant n°821,520. AH received a PhD grant from EHESP.
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影响因子：
5.1
作者：
Beune, Irene M.;Bloomfield, Frank H.;Gordijn, Sanne J.
通讯作者：
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1.8
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影响因子：
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影响因子：
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影响因子：
15.8
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Kiserud T;Piaggio G;Carroli G;Widmer M;Carvalho J;Neerup Jensen L;Giordano D;Cecatti JG;Abdel Aleem H;Talegawkar SA;Benachi A;Diemert A;Tshefu Kitoto A;Thinkhamrop J;Lumbiganon P;Tabor A;Kriplani A;Gonzalez Perez R;Hecher K;Hanson MA;Gülmezoglu AM;Platt LD
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