Autoantibody profile in sarcoidosis, analysis from the GRADS sarcoidosis cohort.
Autoantibody profile in sarcoidosis, analysis from the GRADS sarcoidosis cohort.
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DOI：
10.1371/journal.pone.0274381
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
结节病是一种多系统肉芽肿性疾病，主要是t细胞疾病，但体液免疫在疾病发病机制中的作用的证据越来越多。利用α -1抗胰蛋白酶缺乏症和结节病（梯度）研究的基因组研究样本，我们检测了与正常对照相比，仅肺和肺外器官累及的结节病患者中自身抗体的患病率。我们利用IgM和IgG抗体的自身抗原微阵列平台分析了参与梯度研究的结节病患者的血清样本。该队列包括结节病合并肺部疾病（POS, n = 106）、结节病合并肺外疾病（EPS, n = 120）和正常对照（NC, n = 101）。所有毕业生参与中心的器官受累情况按照标准化格式进行评估。与正常对照相比，结节病患者总体上IgM和IgG自身抗体水平升高。此外，与NC组相比，POS组和EPS组中有几种自身抗体升高。在POS组和EPS组之间也注意到自身抗体水平的差异。与结节病的脏器累及比较，骨、脾、耳、鼻、喉的IgM表达高于其他脏器。与正常对照相比，结节病患者IgM和IgG自身抗体水平升高。此外，肺和其他器官受累的个体有更高的IgM表达。特异性器官-自身抗体对及其在疾病发病机制中的作用有待进一步研究。
Sarcoidosis, a multi-systemic granulomatous disease, is a predominantly T-cell disease but evidence for a role for humoral immunity in disease pathogenesis is growing. Utilizing samples from the Genomic Research in Alpha-1 anti-trypsin Deficiency and Sarcoidosis (GRADS) study, we examined the prevalence of autoantibodies in sarcoidosis patients with pulmonary-only and extra-pulmonary organ involvement compared to normal controls. We analyzed serum samples from sarcoidosis patients who participated in the GRADS study utilizing an autoantigen microarray platform for both IgM and IgG antibodies. The cohort included sarcoidosis patients with pulmonary-only disease (POS, n = 106), sarcoidosis patients with extra-pulmonary disease (EPS, n = 120) and a normal control cohort (NC, n = 101). Organ involvement was assessed following a standardized format across all GRADS participating centers. Sarcoidosis patients overall had increased levels of IgM and IgG autoantibodies compared to normal controls. In addition, several autoantibodies were elevated in the POS and EPS cohorts compared to the NC cohort. Differences in autoantibody levels were also noted between the POS and the EPS cohorts. When comparing organ involvement with sarcoidosis, bone, spleen and ear, nose and throat involvement had higher IgM expression than other organs. Sarcoidosis patients have elevated IgM and IgG autoantibody levels compared to normal controls. In addition, individuals with pulmonary as well as additional organ involvement had higher IgM expression. Further research is needed focusing on specific organ-autoantibody pairs and role of autoantibodies in disease pathogenesis.
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影响因子：
7.3
作者：
Kinloch AJ;Kaiser Y;Wolfgeher D;Ai J;Eklund A;Clark MR;Grunewald J
通讯作者：
Grunewald J
影响因子：
3.4
作者：
Ando, Masaru;Goto, Akihiko;Kadota, Jun-ichi
通讯作者：
Kadota, Jun-ichi
影响因子：
--
作者：
Hueber, W;Kidd, BA;Robinson, WH
通讯作者：
Robinson, WH
DOI：
10.1164/rccm.202002-0251st
发表时间：
2020-04-15
影响因子：
24.7
作者：
Crouser, Elliott D.;Maier, Lisa A.;Baughman, Robert P.
通讯作者：
Baughman, Robert P.
影响因子：
5.1
作者：
Lammert C;Zhu C;Lian Y;Raman I;Eckert G;Li QZ;Chalasani N
通讯作者：
Chalasani N