Modeling upper airway collapse by a finite element model with regional tissue properties.
Modeling upper airway collapse by a finite element model with regional tissue properties.
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DOI：
10.1016/j.medengphy.2009.08.006
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发表时间：
2009-12
影响因子：
2.2
通讯作者：
Wootton, David M.
中科院分区：
文献类型：
--
作者：
Xu, Chun;Brennick, Michael J.;Dougherty, Lawrence;Wootton, David M.
本研究提出了一种新的计算系统，结合标记的磁共振成像（MRI）与组织材料的属性来预测三维（3D）气道运动的大鼠上气道建模。该模型能够预测气道压力负荷下气道壁和组织变形直至气道塌陷。该模型表明，口咽塌陷压力主要取决于腹侧壁（舌肌）的弹性模量和气道结构。一种迭代方法，涉及替代替代可能的组织弹性模量被用来提高模型精度。所提出的3D模型解释了复杂上气道的应力-应变关系，为理解气道塌陷的发病机制、改善诊断和开发治疗方法提供了新的机会。
This study presents a new computational system for modeling the upper airway in rats that combines tagged magnetic resonance imaging (MRI) with tissue material properties to predict three-dimensional (3D) airway motion. The model is capable of predicting airway wall and tissue deformation under airway pressure loading up to airway collapse. The model demonstrates that oropharynx collapse pressure depends primarily on ventral wall (tongue muscle) elastic modulus and airway architecture. An iterative approach that involves substituting alternative possible tissue elastic moduli was used to improve model precision. The proposed 3D model accounts for stress-strain relationships in the complex upper airway that should present new opportunities for understanding pathogenesis of airway collapse, improving diagnosis and developing treatments.
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影响因子：
2.6
作者：
Huang, Yaqi;White, David P.;Malhotra, Atul
通讯作者：
Malhotra, Atul
影响因子：
19.7
作者：
AXEL, L;DOUGHERTY, L
通讯作者：
DOUGHERTY, L
影响因子：
5.5
作者：
Brennick, MJ;Pickup, S;Kuna, ST
通讯作者：
Kuna, ST
影响因子：
3.3
作者：
SCHWARTZ, AR;SMITH, PL;PERMUTT, S
通讯作者：
PERMUTT, S
DOI：
10.1164/rccm.200505-705oc
发表时间：
2006-05-01
影响因子：
24.7
作者：
Brennick, MJ;Pickup, S;Kuna, ST
通讯作者：
Kuna, ST