Usefulness of Atrial Premature Complexes on Routine Electrocardiogram to Determine the Risk of Atrial Fibrillation (from the REGARDS Study).
Usefulness of Atrial Premature Complexes on Routine Electrocardiogram to Determine the Risk of Atrial Fibrillation (from the REGARDS Study).
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DOI：
10.1016/j.amjcard.2017.06.007
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发表时间：
2017-09-01
期刊：
影响因子：
--
通讯作者：
Soliman EZ
中科院分区：
文献类型：
--
作者：
O'Neal WT;Kamel H;Judd SE;Safford MM;Vaccarino V;Howard VJ;Howard G;Soliman EZ
房性早搏复合波（APC）是房颤（AF）的急性触发因素，但目前尚不清楚APC与AF之间的关联是否因种族或性别而异。我们在卒中地理和种族差异原因研究的13，840名参与者（平均年龄=63±8.4岁; 56%为女性; 37%为黑人）中检查了APC与AF之间的关系。在基线心电图上检测到APC（2003-2007年）。通过研究计划的心电图和随访检查时自我报告的病史确定AF事件。Logistic回归用于计算APC与AF事件之间关联的比值比（OR）和95%置信区间（CI）。共有950名（6.9%）参与者在基线访视时患有APC。在中位随访9.4年后，检测到1，015例（7.3%）AF事件。APC与AF风险增加相关（OR=1.92，95%CI=1.57，2.35）。APC和AF之间的关系不因种族（相互作用p值=0.56）或性别（相互作用p值=0.66）而异。总之，在常规心电图上检测到的APC与AF发生的风险增加相关，并且这种相关性不因种族或性别而异。该分析的结果表明，心房异位相关的房颤风险并不能解释白人与黑人以及男性与女性的房颤风险差异。
Atrial premature complexes (APCs) serve as acute triggers for atrial fibrillation (AF), but it is currently unknown whether the association between APCs and AF varies by race or sex. We examined the association between APCs and AF in 13,840 (mean age=63±8.4 years; 56% women; 37% black) participants from the REasons for Geographic And Racial Differences in Stroke study. APCs were detected on baseline electrocardiograms (2003–2007). Incident AF was identified by study-scheduled electrocardiograms and self-reported history at a follow-up examination. Logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) for the association between APCs and incident AF. A total of 950 (6.9%) participants had APCs at the baseline visit. After a median follow-up of 9.4 years, 1,015 (7.3%) incident AF cases were detected. APCs were associated with an increased risk of AF (OR=1.92, 95%CI=1.57, 2.35). The relationship between APCs and AF did not vary by race (interaction p-value=0.56) or sex (interaction p-value=0.66). In conclusion, APCs detected on a routine electrocardiogram are associated with an increased risk for AF development, and this association does not vary by race or sex. The findings of this analysis suggest that the AF risk associated with atrial ectopy does not account for the differential risk of AF that is observed in whites compared with blacks, and in men compared with women.
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
6.1
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