Race-specific impact of atrial fibrillation risk factors in blacks and whites in the southern community cohort study.
Race-specific impact of atrial fibrillation risk factors in blacks and whites in the southern community cohort study.
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DOI：
10.1016/j.amjcard.2012.07.032
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发表时间：
2012-12-01
影响因子：
2.8
通讯作者：
Darbar, Dawood
中科院分区：
文献类型：
--
作者：
Lipworth, Loren;Okafor, Henry;Mumma, Michael T.;Edwards, Todd L.;Roden, Dan M.;Blot, William J.;Darbar, Dawood
尽管传统危险因素的负担更大，但房颤（AF）在黑人中比白人更少见，原因尚不清楚。我们研究了人口统计学、生活方式、人体测量学和医学因素对一大群黑人和白人房颤的种族和性别特异性影响。在南方社区队列研究中，年龄在65岁及以上接受1999-2008年医疗保险覆盖的白人和黑人参与者（n=8,836）中，我们确定了房颤的诊断（ICD-9 CM 427.3）。使用多变量logistic回归计算与参与者特征相关的房颤优势比（ORs），包括在队列进入时确定的高血压、糖尿病、中风和心肌梗死/冠状动脉搭桥手术史。在平均5.7年的医疗保险覆盖期间，1062名参与者被诊断为房颤。黑人房颤患病率（11%）明显低于白人（15%，P< 0.0001）。房颤的OR值随着年龄的增长而上升，在男性、高个子和肥胖者以及患有各种合并症的人群中更高，但在校正这些因素后，黑人与白人相比房颤缺陷仍然存在（OR=0.64, 95% CI 0.55-0.73）。黑人和白人的房颤风险模式相似，尽管黑人与高血压、糖尿病和中风的关联更强。总之，这些发现证实了黑人AF的患病率低于白人，并表明AF的传统危险因素同样适用于两组，因此似乎不能解释黑人AF的悖论。
Despite a greater burden of traditional risk factors, atrial fibrillation (AF) is less common among black than whites for reasons that are unclear. We have examined race- and gender-specific influences of demographic, lifestyle, anthropometric and medical factors on AF in a large cohort of blacks and whites. Among white and black participants in the Southern Community Cohort Study age 65 and older receiving Medicare coverage from 1999–2008 (n=8,836), we ascertained diagnoses of AF (ICD-9 CM 427.3). Multivariate logistic regression was used to compute AF odds ratios (ORs) associated with participant characteristics, including histories of hypertension, diabetes, stroke and myocardial infarction/coronary artery bypass graft surgery, ascertained at cohort entry. Over an average of 5.7 years of Medicare coverage, AF was diagnosed among 1,062 participants. AF prevalence was significantly lower among blacks (11%) than whites (15%; P<.0001). ORs for AF rose with age, were higher among men, the tall and obese, and among persons with each of the comorbid conditions, but the AF deficit among blacks compared with whites persisted upon adjustment for these factors (OR=0.64, 95% CI 0.55–0.73). The patterns of AF risk were similar for blacks and whites, although associations with hypertension, diabetes and stroke were somewhat stronger among blacks. In conclusion, these findings confirm the lower prevalence of AF among blacks than whites and suggest that traditional risk factors for AF apply similarly to both groups and thus do not appear to explain the AF paradox in blacks.
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影响因子：
37.8
作者：
Huxley RR;Lopez FL;Folsom AR;Agarwal SK;Loehr LR;Soliman EZ;Maclehose R;Konety S;Alonso A
通讯作者：
Alonso A
DOI：
10.1161/circoutcomes.111.962688
发表时间：
2012-01
期刊：
Circulation. Cardiovascular quality and outcomes
影响因子：
--
作者：
Piccini JP;Hammill BG;Sinner MF;Jensen PN;Hernandez AF;Heckbert SR;Benjamin EJ;Curtis LH
通讯作者：
Curtis LH
影响因子：
37.8
作者：
Magnani, Jared W.;Rienstra, Michiel;Benjamin, Emelia J.
通讯作者：
Benjamin, Emelia J.
影响因子：
7.1
作者：
Shen, Jian;Johnson, Victor M.;Benjamin, Emelia J.
通讯作者：
Benjamin, Emelia J.
影响因子：
120.7
作者：
BENJAMIN, EJ;LEVY, D;WOLF, PA
通讯作者：
WOLF, PA