Serotonergic transcriptional networks and potential importance to mental health.
Serotonergic transcriptional networks and potential importance to mental health.
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DOI：
10.1038/nn.3039
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发表时间：
2012-02-26
影响因子：
25
通讯作者：
中科院分区：
文献类型：
--
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Transcription regulatory networks governing the genesis, maturation and maintenance of vertebrate brain serotonin (5–HT) neurons determine the level of serotonergic gene expression and signaling across the lifespan. Recent work suggests alterations in these networks can cause behavioral and physiological pathogenesis in mice. Here, we synthesize findings from vertebrate loss and gain of function studies to build a new model of the transcriptional regulatory networks that specify 5–HT neurons during fetal life, integrate them into CNS circuitry in early postnatal life and maintain them in adulthood. We then describe findings from animal and human genetic studies that support possible altered activity of serotonergic regulatory networks in the etiology of mental illness. We conclude with a discussion of the potential utility of our model, as an experimentally well–defined molecular pathway, to predict and interpret the biological impact of rare human variation that may be discovered in the network.
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