Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patients.
Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patients.
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DOI：
10.1054/bjoc.2000.1560
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发表时间：
2001-01
影响因子：
8.8
通讯作者：
Malesci A
中科院分区：
文献类型：
--
作者：
Laghi L;Bianchi P;Orbetegli O;Gennari L;Roncalli M;Malesci A
最近在北美患者的晚期结直肠癌亚组中发现了人原癌基因c-src密码子531处的截短突变（C至T转换），可能是c-src酪氨酸激酶激活的原因。然而，随后的两项研究未能证实北欧和亚洲患者的结直肠癌中SRC 531突变的发生，提出了这样的假设，即结肠癌中src的遗传激活可能仅限于属于特定种族的患者。我们调查了意大利患者（155例）的大系列结直肠癌，肝转移的患病率很高（43%）。使用PCR-RFLP分析，在所有研究的原发性肿瘤和/或转移瘤标本中排除了SRC 531突变的发生。我们的研究结果表明，SRC Gln 531 AMB在意大利患者结直肠癌的发展或进展中没有作用。© 2001年癌症研究运动http://www.bjcancer.com
A truncating mutation (C to T transition) at codon 531 of the human protooncogene c-src, possibly accounting for the activation of c-src tyrosine kinase, has been recently identified in a subset of advanced colorectal cancer from North-American patients. However, two subsequent studies have failed to confirm the occurrence of SRC 531 mutation in colorectal cancers from North-European and Asiatic patients, raising the hypothesis that the genetic activation of src in colon cancer might be restricted to patients belonging to specific ethnic groups. We investigated a large series of colorectal cancers from Italian patients (155 cases) with a high prevalence of liver metastasis (43%). Using a PCR-RFLP assay, the occurrence of a SRC 531 mutation was ruled out in all the investigated specimens of primary tumours and/or metastases. Our results demonstrate that SRC Gln531AMB plays no role in the development or in the progression of colorectal cancer among Italian patients. © 2001 Cancer Research Campaign http://www.bjcancer.com
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