Pregnancy and weaning regulate human maternal liver size and function.
Pregnancy and weaning regulate human maternal liver size and function.
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DOI：
10.1073/pnas.2107269118
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发表时间：
2021-11-30
影响因子：
11.1
通讯作者：
Schedin P
中科院分区：
文献类型：
--
作者：
Q Bartlett A;Vesco KK;Purnell JQ;Francisco M;Goddard E;Guan X;DeBarber A;Leo MC;Baetscher E;Rooney W;Naugler W;Guimaraes AR;Catalano P;Xia Z;Schedin P
这些人类数据与女性肝脏大小和功能的生殖控制一致，并与最近在啮齿动物中的观察结果一致，表明肝脏生物学是保守的。这种描述的肝脏生物学是否对怀孕期间的孕产妇健康或性别特异性肝病风险有影响的问题仍有待确定。然而，我们的证据表明，女性断奶诱导的肝脏退化可能会提高对年轻产后乳腺癌患者中观察到的高肝转移率的理解。在怀孕期间，啮齿动物的肝脏经历肝细胞增殖和大小增加，随后断奶诱导的内陷通过肝细胞死亡和基质重塑，创造一个前转移生态位。这些数据提示近期分娩的乳腺癌患者肝转移增加的机制。目前尚不清楚人类肝脏在怀孕和断奶期间是否会改变大小和功能。本研究对妊娠早期、晚期和产后的健康妇女进行了腹部影像学检查。测定妊娠各时间点葡萄糖的产生、利用和循环胆汁酸。与体重增加无关，大多数女性的肝脏在怀孕期间会增大，然后在断奶后恢复到基线水平。观察了胆汁酸在肝脏生长和退化中的推测作用。综上所述，这些数据支持了人类肝脏受生殖状态调节的假设，即怀孕期间的生长和断奶后的体积损失。这些发现对性别特异性肝脏疾病和乳腺癌的预后具有启示意义。
These human data are consistent with reproductive control of liver size and function in women and concur with recent observations in rodents, suggesting a conserved liver biology. The question of whether this described liver biology has implications for maternal health during pregnancy or sex-specific risk for liver disease remains to be determined. However, our evidence suggestive of weaning-induced liver involution in women may lead to improved understanding of the high rates of liver metastasis observed in young postpartum breast cancer patients. During pregnancy, the rodent liver undergoes hepatocyte proliferation and increases in size, followed by weaning-induced involution via hepatocyte cell death and stromal remodeling, creating a prometastatic niche. These data suggest a mechanism for increased liver metastasis in breast cancer patients with recent childbirth. It is unknown whether the human liver changes in size and function during pregnancy and weaning. In this study, abdominal imaging was obtained in healthy women at early and late pregnancy and postwean. During pregnancy time points, glucose production and utilization and circulating bile acids were measured. Independently of weight gain, most women’s livers increased in size with pregnancy, then returned to baseline postwean. Putative roles for bile acids in liver growth and regression were observed. Together, the data support the hypothesis that the human liver is regulated by reproductive state with growth during pregnancy and volume loss postwean. These findings have implications for sex-specific liver diseases and for breast cancer outcomes.
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影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
影响因子：
--
作者：
BERLANGA, JJ;VARA, JAF;GARCIARUIZ, JP
通讯作者：
GARCIARUIZ, JP
影响因子：
6.8
作者：
Hu，Yun;Ding，Yiling;Xiang，Zhongyuan
通讯作者：
Xiang，Zhongyuan
影响因子：
5.2
作者：
Bartlett AQ;Pennock ND;Klug A;Schedin P
通讯作者：
Schedin P
影响因子：
28.2
作者：
Goddard, Erica T.;Hill, Ryan C.;Schedin, Pepper
通讯作者：
Schedin, Pepper