Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration.
Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration.
复制标题
通过生物材料的表面修饰调节免疫炎症反应，以促进骨愈合和再生。
DOI：
10.1177/20417314211041428
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发表时间：
2021-01
影响因子：
8.2
通讯作者：
Huck O
中科院分区：
文献类型：
--
作者：
Batool F;Özçelik H;Stutz C;Gegout PY;Benkirane-Jessel N;Petit C;Huck O
控制炎症对于口腔伤口愈合和组织再生是必不可少的。几种生物材料已被用于提高再生结果；然而，生物材料的植入可以确保免疫炎症反应。细胞与生物材料表面之间的界面对软硬组织再生的成功与否起着至关重要的作用。生物材料植入后的初始炎症反应有助于组织修复和再生，然而，持续的炎症会损害伤口愈合反应。细胞通过细胞外基质蛋白与生物材料相互作用，导致蛋白质吸附，随后是一些免疫炎症细胞的募集、附着、迁移和增殖。生物材料的物理纳米形貌，如表面蛋白质、粗糙度和孔隙度，对于驱动细胞附着和迁移至关重要。同样，通过调整亲水性、表面电荷、表面涂层来修饰支架表面化学，可以下调促炎级联反应的启动。此外，活性生物分子功能化支架表面可以下调促炎和促吸收介质的释放，积极上调抗炎标志物。本文综述了优化生物材料的物理、化学和生物学特性的各种策略，以及调节免疫炎症反应的潜在机制，从而促进组织整合和随后给予生物材料的软硬组织再生潜力。
Control of inflammation is indispensable for optimal oral wound healing and tissue regeneration. Several biomaterials have been used to enhance the regenerative outcomes; however, the biomaterial implantation can ensure an immune-inflammatory response. The interface between the cells and the biomaterial surface plays a critical role in determining the success of soft and hard tissue regeneration. The initial inflammatory response upon biomaterial implantation helps in tissue repair and regeneration, however, persistant inflammation impairs the wound healing response. The cells interact with the biomaterials through extracellular matrix proteins leading to protein adsorption followed by recruitment, attachment, migration, and proliferation of several immune-inflammatory cells. Physical nanotopography of biomaterials, such as surface proteins, roughness, and porosity, is crucial for driving cellular attachment and migration. Similarly, modification of scaffold surface chemistry by adapting hydrophilicity, surface charge, surface coatings, can down-regulate the initiation of pro-inflammatory cascades. Besides, functionalization of scaffold surfaces with active biological molecules can down-regulate pro-inflammatory and pro-resorptive mediators’ release as well as actively up-regulate anti-inflammatory markers. This review encompasses various strategies for the optimization of physical, chemical, and biological properties of biomaterial and the underlying mechanisms to modulate the immune-inflammatory response, thereby, promoting the tissue integration and subsequent soft and hard tissue regeneration potential of the administered biomaterial.
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影响因子：
14
作者：
Chen, Sulin;Jones, Jacqueline A.;Xu, Yongan;Low, Hong-Yee;Anderson, James M.;Leong, Kam W.
通讯作者：
Leong, Kam W.
影响因子：
6.2
作者：
Al-Khoury, Hala;Espinosa-Cano, Eva;Groth, Thomas
通讯作者：
Groth, Thomas
影响因子：
14
作者：
Abaricia, Jefferson O.;Shah, Arth H.;Olivares-Navarrete, Rene
通讯作者：
Olivares-Navarrete, Rene
影响因子：
4.9
作者：
Babensee, JE;Paranjpe, A
通讯作者：
Paranjpe, A
影响因子：
17.1
作者：
Chen, Zetao;Bachhuka, Akash;Xiao, Yin
通讯作者：
Xiao, Yin