Fir(e)ing the Rhythm: Inflammatory Cytokines and Cardiac Arrhythmias.
Fir(e)ing the Rhythm: Inflammatory Cytokines and Cardiac Arrhythmias.
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DOI：
10.1016/j.jacbts.2022.12.004
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发表时间：
2023-06
影响因子：
9.7
通讯作者：
Capecchi, Pier Leopoldo
中科院分区：
文献类型：
--
作者：
Lazzerini, Pietro Enea;Abbate, Antonio;Boutjdir, Mohamed;Capecchi, Pier Leopoldo
心律失常是发病率和死亡率的主要原因，至少部分原因是对临床管理产生负面影响的基本机制的知识存在差距。炎症激活越来越多地被认为是心律失常的非传统危险因素：本文将讨论促炎细胞因子及其在临床环境中的翻译影响的促心律失常作用的基本机制。基于本文综述的基础和临床研究提供的强大背景，大型随机临床试验有必要验证抗细胞因子靶向治疗是否可以代表治疗和预防心律失常的新的重要途径。炎症激活越来越多地被认为是心律失常的非传统风险因素，实验研究提供了强有力的证据表明，这种关联是由促炎细胞因子对心脏细胞的直接致心律失常作用介导的。此外，炎性细胞因子可通过多种全身效应间接促进心律失常。累积的数据证实了这些机制的临床相关性;最大的证据是房颤、获得性长QT综合征和室性心律失常。然而，心律失常的临床管理在很大程度上忽略了炎性细胞因子。这篇综述整合了基础科学和临床研究，提出了一个更新的概述，并为患者的管理提供了未来的方向。
Cardiac arrhythmias are a leading cause of morbidity and mortality, at least in part because of gaps in the knowledge of the fundamental mechanisms that negatively affect clinical management. Inflammatory activation is increasingly recognized as a nonconventional risk factor for arrhythmias: this review will discuss the basic mechanisms underlying arrhythmogenic effects of proinflammatory cytokines and their translational affect in the clinical setting. Based on the strong background provided by the basic and clinical studies here reviewed, large randomized clinical trials are warranted to verify whether anticytokine-targeted therapies can represent a new important avenue for the treatment and prevention of cardiac arrhythmias. Inflammatory activation is increasingly recognized as a nonconventional risk factor for arrhythmias, and experimental studies provided robust evidence that this association is mediated by direct arrhythmogenic effects of proinflammatory cytokines on cardiac cells. Additionally, inflammatory cytokines can favor arrhythmias indirectly through multiple systemic effects. Accumulating data confirm the clinical relevance of these mechanisms; the largest evidence being available for atrial fibrillation, acquired long-QT syndrome, and ventricular arrhythmias. However, clinical management of arrhythmias largely neglects inflammatory cytokines. This review integrates basic science and clinical research to present an updated overview of the topic and provides future directions for patient’s management.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1093/ehjcvp/pvab075
发表时间：
2021-10-07
影响因子：
7.1
作者：
Abbate, Antonio;Wohlford, George F.;Van Tassell, Benjamin W.
通讯作者：
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