RNA helicase proteins as chaperones and remodelers.
RNA helicase proteins as chaperones and remodelers.
复制标题
DOI：
10.1146/annurev-biochem-060713-035546
复制
发表时间：
2014
影响因子：
16.6
通讯作者：
Russell R
中科院分区：
文献类型：
--
作者：
Jarmoskaite I;Russell R
超家族2解旋酶蛋白在RNA生物学中普遍存在，并且具有非常广泛的功能作用。这些作用中的中心是促进结构化RNA的重排和重塑RNA-蛋白质复合物（RNP），允许天然RNA结构的形成或通过结构的功能循环的进展。虽然所有超家族2解旋酶共享一个保守的解旋酶核心，但它们在进化上分为几个家族，并且主要是来自三个家族的蛋白质，DEAD-盒、DEAH/RHA和Ski 2-样家族，其功能是操纵结构化RNA和RNP。引人注目的是，这些蛋白质的机制出现了差异，无论是在家族之间还是在最大的家族（DEAD盒）内，这些差异似乎与它们的RNA或RNP底物及其特定作用有关。本文综述了这三个家族的基本机制特征，并调查了单个蛋白质及其生物学底物和机制的当前理解。
Superfamily 2 helicase proteins are ubiquitous in RNA biology and have an extraordinarily broad set of functional roles. Central among these roles are to promote rearrangements of structured RNAs and to remodel RNA-protein complexes (RNPs), allowing formation of native RNA structure or progression through a functional cycle of structures. While all superfamily 2 helicases share a conserved helicase core, they are divided evolutionarily into several families, and it is principally proteins from three families, the DEAD-box, DEAH/RHA and Ski2-like families, that function to manipulate structured RNAs and RNPs. Strikingly, there are emerging differences in the mechanisms of these proteins, both between families and within the largest family (DEAD-box), and these differences appear to be tuned to their RNA or RNP substrates and their specific roles. This review outlines basic mechanistic features of the three families and surveys individual proteins and the current understanding of their biological substrates and mechanisms.
登录
查看更多内容
影响因子：
2.9
作者：
Bizebard, T;Ferlenghi, I;Dreyfus, M
通讯作者：
Dreyfus, M
影响因子：
16.8
作者：
Buettner, Katharina;Nehring, Sebastian;Hopfner, Karl-Peter
通讯作者：
Hopfner, Karl-Peter
影响因子：
4.8
作者：
Abu Dayyeh, BK;Quan, TK;Ruby, SW
通讯作者：
Ruby, SW
影响因子：
5.6
作者：
Bifano, Abby L.;Caprara, Mark G.
通讯作者：
Caprara, Mark G.
DOI：
10.1073/pnas.94.22.11798
发表时间：
1997-10-28
影响因子：
11.1
作者：
Arenas, JE;Abelson, JN
通讯作者：
Abelson, JN