A comparison of epithelial-to-mesenchymal transition and re-epithelialization.
A comparison of epithelial-to-mesenchymal transition and re-epithelialization.
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DOI：
10.1016/j.semcancer.2012.07.003
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发表时间：
2012-10
影响因子：
14.5
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Leopold PL;Vincent J;Wang H
伤口愈合和癌症转移有一个共同的起点，即一些细胞的表型从静止变为运动。上皮间质转化 (EMT) 一词描述了分子生物学和细胞生理学的变化，使细胞从静止细胞转变为运动细胞，这一过程不仅与癌症和再生有关，而且与多细胞生物的正常发育有关。本综述在分子水平上比较了肿瘤细胞进入 EMT 或角质形成细胞开始伤口上皮再形成过程时细胞反应的异同。着眼于可能调节这些过程的临床干预措施，对与 EMT 核心途径相关的抗癌和促进伤口愈合治疗的当前和潜在疗法的机制和结果进行了审查。总而言之，上皮再形成和肿瘤 EMT 的比较可以作为开发可选择性调节不同形式 EMT 的疗法的起点。
Wound healing and cancer metastasis share a common starting point, namely, a change in the phenotype of some cells from stationary to motile. The term, epithelial-to-mesenchymal transition (EMT) describes the changes in molecular biology and cellular physiology that allow a cell to transition from a sedentary cell to a motile cell, a process that is relevant not only for cancer and regeneration, but also for normal development of multicellular organisms. The present review compares the similarities and differences in cellular response at the molecular level as tumor cells enter EMT or as keratinocytes begin the process of re-epithelialization of a wound. Looking toward clinical interventions that might modulate these processes, the mechanisms and outcomes of current and potential therapies are reviewed for both anti-cancer and pro-wound healing treatments related to the pathways that are central to EMT. Taken together, the comparison of re-epithelialization and tumor EMT serves as a starting point for the development of therapies that can selectively modulate different forms of EMT.
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影响因子：
6
作者：
Boucher, Ilene;Kehasse, Amanuel;Trinkaus-Randall, Vickery
通讯作者：
Trinkaus-Randall, Vickery
影响因子：
8.8
作者：
Bryant, J. L.;Britson, J.;Balko, J. M.;Willian, M.;Timmons, R.;Frolov, A.;Black, E. P.
通讯作者：
Black, E. P.
影响因子：
3.3
作者：
Arnoux, Valerie;Nassour, Mayssaa;Savagner, Pierre
通讯作者：
Savagner, Pierre
DOI：
10.1083/jcb.109.4.1495
发表时间：
1989-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Boyer B;Tucker GC;Vallés AM;Franke WW;Thiery JP
通讯作者：
Thiery JP
影响因子：
8
作者：
Blanco, MJ;Moreno-Bueno, G;Nieto, MA
通讯作者：
Nieto, MA