Modulation of neural activity during object naming: effects of time and practice.
Modulation of neural activity during object naming: effects of time and practice.
复制标题
物体命名过程中神经活动的调节：时间和实践的影响。
作者：
M. van Turennout;Lisa Bielamowicz;Alex Martin
反复接触物体会提高我们识别和命名它们的能力，即使是在很长一段时间之后。之前的脑成像研究已经证明，这种与经验相关的物体命名便利化与不同大脑区域的神经变化有关。我们使用事件相关功能磁共振成像(FMRI)来研究物体命名系统中神经活动作为经验和时间函数的调制。在扫描前的不同时间间隔(1h、6h和3d)或在扫描过程中以30个S间隔重复呈现常见对象的图像以进行命名。结果显示，随着被试对经验的熟悉，枕颞区和左下额下区的活动减少，而左脑岛和基底节的活动增加。在后部区域，多次重复导致的活动减少与时间没有交互作用，而在左下额叶皮质，当重复随时间间隔时，观察到更大的减少。这种对不同大脑区域活动的不同调节为长时间物体启动是由两种神经机制介导的观点提供了支持。第一种机制可能涉及枕颞叶皮质特定对象表征的改变，第二种机制可能是一种程序性学习形式，涉及大脑回路的重组，从而导致更有效的名字提取。
Repeated exposure to objects improves our ability to identify and name them, even after a long delay. Previous brain imaging studies have demonstrated that this experience-related facilitation of object naming is associated with neural changes in distinct brain regions. We used event-related functional magnetic resonance imaging (fMRI) to examine the modulation of neural activity in the object naming system as a function of experience and time. Pictures of common objects were presented repeatedly for naming at different time intervals (1 h, 6 h and 3 days) before scanning, or at 30 s intervals during scanning. The results revealed that as objects became more familiar with experience, activity in occipitotemporal and left inferior frontal regions decreased while activity in the left insula and basal ganglia increased. In posterior regions, reductions in activity as a result of multiple repetitions did not interact with time, whereas in left inferior frontal cortex larger decreases were observed when repetitions were spaced out over time. This differential modulation of activity in distinct brain regions provides support for the idea that long-lasting object priming is mediated by two neural mechanisms. The first mechanism may involve changes in object-specific representations in occipitotemporal cortices, the second may be a form of procedural learning involving a reorganization in brain circuitry that leads to more efficient name retrieval.
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影响因子：
14.5
作者：
Buckner, RL;Koutstaal, W;Rosen, BR
通讯作者：
Rosen, BR
影响因子：
3.7
作者：
A. Wagner;W. Koutstaal;Anat Maril;D. Schacter;R. Buckner;R. Buckner
通讯作者：
A. Wagner;W. Koutstaal;Anat Maril;D. Schacter;R. Buckner;R. Buckner
DOI：
10.1006/cbmr.1996.0014
发表时间：
1996-06-01
期刊：
COMPUTERS AND BIOMEDICAL RESEARCH
影响因子：
--
作者：
Cox, RW
通讯作者：
Cox, RW
完整且持久的重复引发失忆症。
DOI：
10.1037//0278-7393.18.3.509
发表时间：
1992
期刊：
Journal of experimental psychology. Learning, memory, and cognition
影响因子：
--
作者：
Cave,CB;Squire,LR
通讯作者：
Squire,LR
影响因子：
3.7
作者：
RAICHLE, ME;FIEZ, JA;PETERSEN, SE
通讯作者：
PETERSEN, SE