Biomarkers associated with mortality in pediatric patients with cardiac arrest and acute respiratory distress syndrome.
Biomarkers associated with mortality in pediatric patients with cardiac arrest and acute respiratory distress syndrome.
复制标题
与心脏骤停和急性呼吸窘迫综合征患儿死亡率相关的生物标志物
DOI：
10.1016/j.resuscitation.2021.11.036
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发表时间：
2022-01
期刊：
影响因子：
6.5
通讯作者：
Yehya N
中科院分区：
文献类型：
--
作者：
Gardner MM;Kirschen MP;Wong HR;McKeone DJ;Scott Halstead E;Thompson JM;Himebauch AS;Topjian AA;Yehya N
To identify plasma biomarkers associated with cardiac arrest in a cohort of children with acute respiratory distress syndrome (ARDS), and to assess the association of these biomarkers with mortality in children with cardiac arrest and ARDS (ARDS+CA). This was a secondary analysis of a single-center prospective cohort study of children with ARDS from 2014-2019 with 17 biomarkers measured. Clinical characteristics and biomarkers were compared between subjects with ARDS+CA and ARDS with univariate analysis. In a sub-cohort of ARDS+CA subjects, the association between biomarker levels and mortality was tested using univariate and bivariate logistic regression. Biomarkers were measured in 333 subjects: 301 with ARDS (median age 5.3 years, 55.5% male) and 32 ARDS+CA (median age 8 years, 53.1% male). More arrests (69%) occurred out-of-hospital with a median CPR duration of 11 (IQR 5.5, 25) minutes. ARDS severity, PRISM III score, vasoactive-ionotropic score and extrapulmonary organ failures were worse in the ARDS+CA versus ARDS group. Eight biomarkers were elevated in the ARDS+CA versus ARDS cohort: sRAGE, nucleosomes, SP-D, CCL22, IL-6, HSP70, IL-8, and MIP-1b. sRAGE, SP-D, and CCL22 remained elevated when the cohorts were matched for illness severity. When controlling for severity of ARDS and cardiac arrest characteristics, sRAGE, IL-6 and granzyme B were associated with mortality in the ARDS+CA group. sRAGE, IL-6 and granzyme B were associated with cardiac arrest mortality when controlling for illness severity. sRAGE was consistently higher in the ARDS+CA cohort compared to ARDS and retained independent association with mortality.
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影响因子：
6.5
作者：
Fink EL;Berger RP;Clark RS;Watson RS;Angus DC;Panigrahy A;Richichi R;Callaway CW;Bell MJ;Mondello S;Hayes RL;Kochanek PM
通讯作者：
Kochanek PM
影响因子：
11.4
作者：
Erusalimsky JD
通讯作者：
Erusalimsky JD
CTL 衍生的颗粒酶 B 参与大鼠心脏骤停和复苏诱导的海马神经元凋亡
影响因子：
3.4
作者：
Ji, Ning-Ning;Wu, Liang;Zhang, Yong-Mei
通讯作者：
Zhang, Yong-Mei
影响因子：
38.9
作者：
Casserly, Brian;Gerlach, Herwig;Levy, Mitchell M.
通讯作者：
Levy, Mitchell M.
影响因子：
4.1
作者：
Gaies, Michael G.;Gurney, James G.;Hirsch, Jennifer C.
通讯作者：
Hirsch, Jennifer C.